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Description:
DNA mismatch repair protein mutL.
Molecular weight: 64139
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
07-MAR-2006, entry version 29.
Phylogenetic order:
Bacteria Chlamydiae Chlamydiales Chlamydiaceae Chlamydia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_CHLTR:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001328 | AAC68177.1 | - |
| PIR | A71497 | A71497. | |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE001273_GR | CT575.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D/UW-3/Cx;
RX MEDLINE=99000809; PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V.,
RA Davis R.W.;
RT "Genome sequence of an obligate intracellular pathogen of humans:
RT Chlamydia trachomatis.";
RL Science 282:754-759(1998).
Feature:
CHAIN 1 576 DNA mismatch repair protein mutL.
/FTId=PRO_0000177939.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 576
MSLSPSRIRL LDSVTVNQIS AGEVIENAAS VVKELIENSL DAGADEIHIE TLGGGRGQIV
VRDNGVGMDP EEVPVALQRH ATSKIAHFAD IFSLASYGFR GEALPSIASI SKMEIHTARA
GGLGSKTLIE KGEPVCCEPA PRQQGTTIAV HSLFYNVPMR QSFQKSPQMD RLAIRRLLEN
SVLSSEGIGW TWISECRQEL YVAKKQGFIE RVALVLGESF VQEAFFIDKQ QGDLRVLGFL
GSPNQHRSTR QGQRLFINNR AVESSFISKK VAEAYAWMIP AQRYPIFVLK LFLPPMWCDF
NVHPQKTEVR LLQEGQISNL LVEAISEALL RRSPSLEETV LKVPTEKIPI ENEGISVPSI
RPAIVSAPLS CPTFSQQPYL KTEMATIVSR DSASSSLSVV EKVRFLTSLG KVLLVEDSEG
VHVVFVQAAR KHLFYVSLLS ERLESRLACQ TFLLPSSVQM TKLEADFLQM RLEALTALGI
ELSRISPDSF AIESAPPFIQ EEELKEWIVA LAQEGALHVG ESFEQLVENT VQKLVFSRNA
RAFDYAWLDI LWKLGKPEKA FDGEMIRRLV LDDDFM