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Description:
DNA mismatch repair protein mutS.
Molecular weight: 92131
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
07-MAR-2006, entry version 33.
Phylogenetic order:
Bacteria Chlamydiae Chlamydiales Chlamydiaceae Chlamydia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_CHLTR:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001351 | AAC68387.1 | - |
| PIR | D71471 | D71471. | |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AE001273_GR | CT792.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D/UW-3/Cx;
RX MEDLINE=99000809; PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V.,
RA Davis R.W.;
RT "Genome sequence of an obligate intracellular pathogen of humans:
RT Chlamydia trachomatis.";
RL Science 282:754-759(1998).
Feature:
CHAIN 1 820 DNA mismatch repair protein mutS.
/FTId=PRO_0000115087.
NP_BIND 618 625 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 820
MTHKLTPMMQ QWHQCKEQAG DCLLLFRLGE FYEAFFDDAL ILAQNLDITL TQRQNVPMSG
IPATCLDGYV DRLVSRGFKV AIAEQADNTE GSKGLVPRTI NRLITPGALL SSSLLPEKAN
NYVLAINQVG SLYGLSCLDL SIGTFLVAEY DNTKDLIEAI CRLAPTELLS HAKFYQKNEA
VIKQLQQHLR ITLSEYVSWA FEYQSATKKL YTCFQVSSLD GFGLQGLVPA INAAGALLSY
IQDKLLLPIS HLSIPKIYGQ QKHLLIDKAS QTNLELLSPI HGEHGKGSLL QVMERTSTPM
GGRLLRNTLI NPFYDLKEIT LRQDSVEFFL QQADLRKILK RQLSCVRDLE RLATKISTSL
ATPKDIGTLR DSLLSCTHIA DNLQNCALPE FLENKFLIAP PLCSLIKTLS TELIQELPLK
VSEGNIFANH YHPDLLRLRN IKENSKSWIL EYQERIRNET GIKKLKVCYA QALGYYIEVA
SNLAPQLPKE FIRRQSRLHA ERFTTQELQQ FQDEVFSVED KLQTLETKLF KELCFYIVEH
RDLILKLSTA VADLDYVVSL AELAAEYDYR RPLVDHSDAL SITKGMHPVA LTLLDKGTFI
PNDTVMHSAQ TRMILLTGPN MAGKSTYIRQ IALLVIMAQM GSFIPARSAH IGIVDKIFTR
IGAGDNLSKG MSTFMVEMAE TANILHNATD RSLVILDEIG RGTSTYDGLA IAQAVVEFLL
FTDGKKAKTL FATHYKELTE LEMHCQHVEN FHAMVKENSG QPIFMYEIVK GHSKKSFGIH
VAKLAGFPLS VVSRAQQILH QFEGPDLRPE PEKAQQLVMF