Description:
Putative Holliday junction resolvase (EC 3.1.-.-).
Molecular weight: 16222
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 2.
07-MAR-2006, entry version 36.
Phylogenetic order:
Bacteria Chlamydiae Chlamydiales Chlamydiaceae Chlamydia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVX_CHLTR:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U15192 | AAA80196.1 | - |
| EMBL | AE001292 | AAC67776.1 | - |
| PIR | A71546 | A71546. | |
| PIR | C56447 | C56447. | |
| GenomeReviews | AE001273_GR | CT184.1 | |
| HAMAP | MF_00651 | - | 1. |
| InterPro | IPR005227 | HJR_YqgF. | |
| InterPro | IPR012337 | RNaseH_fold. | |
| InterPro | IPR006641 | YqgFc. | |
| Pfam | PF03652 | UPF0081 | 1. |
| SMART | SM00732 | YqgFc | 1. |
| TIGRFAMs | TIGR00250 | HJR_YqgF | 1. |
Keywords:
Complete proteome; DNA damage; DNA recombination; DNA repair; Hydrolase; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=L2;
RX MEDLINE=95229596; PubMed=7713886; DOI=10.1074/jbc.270.14.7908;
RA Tipples G., McClarty G.;
RT "Cloning and expression of the Chlamydia trachomatis gene for CTP
RT synthetase.";
RL J. Biol. Chem. 270:7908-7914(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D/UW-3/Cx;
RX MEDLINE=99000809; PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V.,
RA Davis R.W.;
RT "Genome sequence of an obligate intracellular pathogen of humans:
RT Chlamydia trachomatis.";
RL Science 282:754-759(1998).
Feature:
CHAIN 1 148 Putative Holliday junction resolvase.
/FTId=PRO_0000172047.
CONFLICT 128 128 P -> S (in Ref. 1).
Comments:
-!- FUNCTION: Could be a nuclease that resolves Holliday junction
intermediates in genetic recombination.
-!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
-!- SIMILARITY: Belongs to the yqgF HJR family.
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Sequence length: 148
MNIAKQQQAF LGIDYGKKRI GLAFASSPLL IPLPIGNVEA RSSLTLTAQA LVSIIKERAV
TTVVFGNPLP MQKAYASSVQ SEIQELAALI QEMTAIEVIL WDERLSSAQA ERMLKSDCGL
NRKQRKNPSD SLAATLILSS FLDSRKLY