Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 26002
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
07-MAR-2006, entry version 39.
Phylogenetic order:
Bacteria Chlamydiae Chlamydiales Chlamydiaceae Chlamydia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_CHLTR:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001331 | AAC68210.1 | - |
| PIR | C71493 | C71493. | |
| HSSP | P12295 | 1EUG | |
| GenomeReviews | AE001273_GR | CT607.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D/UW-3/Cx;
RX MEDLINE=99000809; PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V.,
RA Davis R.W.;
RT "Genome sequence of an obligate intracellular pathogen of humans:
RT Chlamydia trachomatis.";
RL Science 282:754-759(1998).
Feature:
CHAIN 1 229 Uracil-DNA glycosylase.
/FTId=PRO_0000176084.
ACT_SITE 70 70 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 229
MHEAFTIEQL PPSWQEQLKD EWSQPYWSQL LAFLKSEYAQ ATIYPKKENV FAALQSTPFD
QVRVVILGQD PYHGEGQAHG LSFSVPRGQA LPPSLRNIFQ ELHTDLGIRN ESGCLQAWAD
QGVLLLNTVL TVRAGEAFSH AGRGWERFTD AIVTKLIQNR THVIFVLWGN AARQKCNLLF
QTKHQHAVLA CPHPSPLAAH RGFFGCCHFS KINYLLKKQG KTMINWKIE