Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 68561
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
07-MAR-2006, entry version 34.
Phylogenetic order:
Bacteria Chlamydiae Chlamydiales Chlamydiaceae Chlamydia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_CHLTR:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001351 | AAC68386.1 | - |
| PIR | C71471 | C71471. | |
| GenomeReviews | AE001273_GR | CT791.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D/UW-3/Cx;
RX MEDLINE=99000809; PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V.,
RA Davis R.W.;
RT "Genome sequence of an obligate intracellular pathogen of humans:
RT Chlamydia trachomatis.";
RL Science 282:754-759(1998).
Feature:
CHAIN 1 598 UvrABC system protein C.
/FTId=PRO_0000138296.
DOMAIN 206 241 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 598
MRIEDFSLKD VSSSPGVYLM KDSQGTVLYV GKAKNLRNRL SSYLQKKGDS RKRIPFLMKK
TTDIDTIVVS NETEAILLEN NLIKKYQPRY NVLLKDDKTF FCLSVSLEHP WPRIEAIRTR
ALSPGKKKQW LFGPYVSAEA CYALLEVISL WFPLRTCSDR EFSTRQRPCV LYEMKRCLAP
CVGLCSQTEY QETLDKAVLF LKGDVRSTIS NLEKAIEKAS QEQKFEHAAA LYRTLTLIRQ
TMAKQHVEKF QAYDIDVLGL YRKGSLAIVS VLSVYSGKLL GARYFIFPEN AQEDSALFSS
FILQYYAENP RIPKEIFVPV SLDSPELPYL LNTAEPPKIR CPKTEYGKEL LALAHKNAAE
QAKPFNSITP PYEELQHFFN LSQYPYRIEC YDNAHLQGEH NVGVCIVFEN GLFSPKQYRT
FSITSHGDDL AAFEEVLTRR FRSLTTELPN LIVIDGGRNQ FKRAQRILEE LNLTGITVVT
IAKESGNHSK SLRQEKLFCE TFPQGILLHP TSAILQFFQL LRDEAHRFAI QHYRKKHAKA
VLTTKKIPGI GEVKTKRLLQ KFKSWKRVFI ASEEELKTVQ GITAKDIQRI QEEGAKPE