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Description:
DNA mismatch repair protein mutH (Methyl-directed mismatch repairprotein).
Molecular weight: 25368
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
13-APR-2004, integrated into UniProtKB/Swiss-Prot.
13-APR-2004, sequence version 2.
07-MAR-2006, entry version 18.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTH_ECO57:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE005174 | AAG57943.1 | - |
| EMBL | BA000007 | BAB37111.1 | - |
| PIR | C85935 | C85935. | |
| PIR | H91089 | H91089. | |
| SMR | Q8X6K2 | 2-228.1 | |
| GenomeReviews | BA000007_GR | ECs3688.1 | |
| GenomeReviews | AE005174_GR | z4149.1 | |
| BioCyc | ECOL83334-1:ECS3688-MONOMER | -.1 | |
| HAMAP | MF_00759 | - | 1. |
| InterPro | IPR004230 | MutH. | |
| Pfam | PF02976 | MutH | 1. |
| TIGRFAMs | TIGR02248 | mutH_TIGR | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX MEDLINE=21074935; PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA Welch R.A., Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX MEDLINE=21156231; PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli
RT O157:H7 and genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
Feature:
INIT_MET 0 0 By similarity.
CHAIN 1 228 DNA mismatch repair protein mutH.
/FTId=PRO_0000198667.
Comments:
-!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated
GATC sequences. It is involved in DNA mismatch repair (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the mutH family.
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Sequence length: 228
SQPRPLLSPP ETEEQLLAQA QQLSGYTLGE LAALAGLVTP ENLKRDKGWI GVLLEIWLGA
SAGSKPEQDF AALGVELKTI PVDSLGRPLE TTFVCVAPLT GNSGVTWETS HVRHKLKRVL
WIPVEGERSI PLAQRRVGSP LLWSPNEEED RQLREDWEEL MDMIVLGQVE RITARHGEYL
QIRPKAANAK ALTEAIGARG ERILTLPRGF YLKKNFTSAL LARHFLIQ