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Description:
DNA mismatch repair protein mutL.
Molecular weight: 67922
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 29.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_ECO57:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE005174 | AAG59366.1 | - |
| EMBL | BA000007 | BAB38569.1 | - |
| PIR | B86113 | B86113. | |
| PIR | B91272 | B91272. | |
| PDB | 1NHH | X-ray | A=1-331. |
| PDB | 1NHI | X-ray | A=1-331. |
| PDB | 1NHJ | X-ray | A=1-331. |
| SMR | Q8XDN4 | 433-614.1 | |
| GenomeReviews | BA000007_GR | ECs5146.1 | |
| GenomeReviews | AE005174_GR | z5777.1 | |
| BioCyc | ECOL83334-1:ECS5146-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
3D-structure; Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX MEDLINE=21074935; PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA Welch R.A., Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX MEDLINE=21156231; PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli
RT O157:H7 and genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
Feature:
CHAIN 1 615 DNA mismatch repair protein mutL.
/FTId=PRO_0000177944.
STRAND 1 1
STRAND 4 5
HELIX 8 19
STRAND 22 22
HELIX 23 36
TURN 37 38
STRAND 40 47
HELIX 48 50
TURN 51 51
STRAND 52 58
STRAND 60 60
HELIX 65 72
STRAND 73 73
TURN 74 75
STRAND 76 79
STRAND 82 82
HELIX 83 87
TURN 88 88
STRAND 91 92
STRAND 95 96
HELIX 98 104
TURN 105 105
STRAND 106 113
TURN 115 116
STRAND 118 126
TURN 127 130
STRAND 131 137
STRAND 141 149
TURN 150 153
HELIX 155 158
TURN 159 160
HELIX 164 181
TURN 183 184
STRAND 185 191
TURN 192 193
STRAND 194 199
TURN 204 205
STRAND 208 208
HELIX 209 216
HELIX 218 223
STRAND 224 231
TURN 232 233
STRAND 234 241
HELIX 243 245
TURN 248 249
HELIX 250 252
STRAND 254 258
TURN 259 260
STRAND 261 263
HELIX 266 279
STRAND 280 282
STRAND 288 293
HELIX 296 298
STRAND 299 300
STRAND 303 304
TURN 305 306
STRAND 311 312
TURN 313 314
HELIX 315 329
TURN 330 330
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 615
MPIQVLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIERGG AKLIRIRDNG
CGIKKDELAL ALARHATSKI ASLDDLEAII SLGFRGEALA SISSVSRLTL TSRTAEQQEA
WQAYAEGRDM DVTVKPAAHP VGTTLEVLDL FYNTPARRKF LRTEKTEFNH IDEIIRRIAL
ARFDVTINLS HNGKIVRQYR AVPEGGQKER RLGAICGTAF LEQALAIEWQ HGDLTLRGWV
ADPNHTTPAL AEIQYCYVNG RMMRDRLINH AIRQACEDKL GADQQPAFVL YLEIDPHQVD
VNVHPAKHEV RFHQSRLVHD FIYQGVLSVL QQQLETPLPL DDEPQPAPRP IPENRVAAGR
NHFAEPAVRE PVAPRYTPAP ASGSRPAAPW PNAQPGYQKQ QGEVYRQLLQ TPAPMQKPKA
PEPQEPALAA NSQSFGRVLT IVHSDCALLE RDGNISLLAL PVAERWLRQV QLTPGEAPVC
AQPLLIPLRL KVSGEEKSAL EKAQSALAEL GIDFQSDAQH VTIRAVPLPL RQQNLQILIP
ELIGYLAKQS VFEPGNIAQW IARNLMSENA QWSMAQAITL LADVERLCPQ LVKTPPGGLL
QSVDLHPAIK ALKDE