Description:
Protein umuD (EC 3.4.21.-) [Contains: Protein umuD'].
Molecular weight: 15063
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
01-NOV-1986, sequence version 1.
07-MAR-2006, entry version 5.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UMUD_ECO57:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE005174 | AAG56034.1 | - |
| EMBL | BA000007 | BAB35101.1 | - |
| PIR | F85696 | F85696. | |
| PIR | F90838 | F90838. | |
| MEROPS | S24.003 | -. | |
| GenomeReviews | BA000007_GR | ECs1678.1 | |
| GenomeReviews | AE005174_GR | z1946.1 |
Keywords:
Autocatalytic cleavage; Complete proteome; DNA damage; DNA repair; Hydrolase; Protease; Serine protease; SOS mutagenesis; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX MEDLINE=21074935; PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA Welch R.A., Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX MEDLINE=21156231; PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli
RT O157:H7 and genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
Feature:
CHAIN 1 139 Protein umuD.
/FTId=PRO_0000045244.
CHAIN 25 139 Protein umuD'.
/FTId=PRO_0000045246.
ACT_SITE 60 60 Involved in auto-cleavage (By
similarity).
ACT_SITE 97 97 Involved in auto-cleavage (By
similarity).
SITE 24 25 Cleavage (auto-) (By similarity).
Comments:
-!- FUNCTION: Involved in UV protection and mutation. Essential for
induced (or SOS) mutagenesis. May modify the DNA replication
machinery to allow bypass synthesis across a damaged template (By
similarity).
-!- SIMILARITY: Belongs to the peptidase S24 family.
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Sequence length: 139
MLFIKPADLR EIVTFPLFSD LVQCGFPSPA ADYVEQRIDL NQLLIQHPSA TYFVKASGDS
MIDGGISDGD LLIVDSAITA SHGDIVIAAV DGEFTVKKLQ LRPTVQLIPM NSAYSPITIS
SEDTLDVFGV VIHVVKAMR