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Description:
DNA ligase (EC 6.5.1.2) (Polydeoxyribonucleotide synthase [NAD+]).
Molecular weight: 73910
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
07-MAR-2006, entry version 41.
Phylogenetic order:
Bacteria Chlamydiae Chlamydiales Chlamydiaceae Chlamydophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DNLJ_CHLPN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001601 | AAD18302.1 | - |
| EMBL | AE002220 | AAF38439.1 | - |
| EMBL | BA000008 | BAA98359.1 | - |
| EMBL | AE017157 | AAP98083.1 | - |
| PIR | B72114 | B72114. | |
| PIR | E86509 | E86509. | |
| HSSP | O87703 | 1B04 | |
| GenomeReviews | AE002161_GR | CP0624.1 | |
| GenomeReviews | AE009440_GR | CpB0150.1 | |
| GenomeReviews | AE001363_GR | CPn0149.1 | |
| GenomeReviews | BA000008_GR | ligA.1 | |
| TIGR | CP0624 | -. | |
| BioCyc | CPNE115711:CP0624-MONOMER | -.1 | |
| BioCyc | CPNE115713:CPN0149-MONOMER | -.1 | |
| BioCyc | CPNE138677:CPJ0149-MONOMER | -.1 | |
| BioCyc | CPNE182082:CPB0150-MONOMER | -.1 | |
| InterPro | IPR001357 | BRCT. | |
| InterPro | IPR004150 | DNA_ligase_OB. | |
| InterPro | IPR001679 | DNAligase. | |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR004149 | Znf_DNAligase_C4. | |
| PANTHER | PTHR11107 | DNAligase.1 | 1. |
| Pfam | PF00533 | BRCT | 1. |
| Pfam | PF01653 | DNA_ligase_aden | 1. |
| Pfam | PF03120 | DNA_ligase_OB | 1. |
| Pfam | PF03119 | DNA_ligase_ZBD | 1. |
| Pfam | PF00633 | HHH | 2. |
| ProDom | PD003944 | DNAligase | 1. |
| SMART | SM00292 | BRCT | 1. |
| SMART | SM00278 | HhH1 | 2. |
| SMART | SM00532 | LIGANc | 1. |
| TIGRFAMs | TIGR00575 | dnlj | 1. |
| PROSITE | PS50172 | BRCT | 1. |
| PROSITE | PS01055 | DNA_LIGASE_N1 | 1. |
| PROSITE | PS01056 | DNA_LIGASE_N2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; DNA replication; Ligase; NAD.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX MEDLINE=99206606; PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX MEDLINE=20150255; PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
RA White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
RA Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
RA Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
RA McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
RT pneumoniae AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX MEDLINE=20330349; PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138
RT from Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 662 DNA ligase.
/FTId=PRO_0000161743.
DOMAIN 583 662 BRCT.
ACT_SITE 115 115 N6-AMP-lysine intermediate (By
similarity).
Comments:
-!- FUNCTION: This protein catalyzes the formation of phosphodiester
linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-
stranded DNA using NAD as a coenzyme and as the energy source for
the reaction. It is essential for DNA replication and repair of
damaged DNA (By similarity).
-!- CATALYTIC ACTIVITY: NAD(+) + (deoxyribonucleotide)(n) +
(deoxyribonucleotide)(m) = AMP + nicotinamide nucleotide +
(deoxyribonucleotide)(n+m).
-!- SIMILARITY: Belongs to the NAD-dependent DNA ligase family.
-!- SIMILARITY: Contains 1 BRCT domain.
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Sequence length: 662
MKEENSQAHY LALCRELEDH DYSYYVLHRP RISDYEYDMK LRKLLEIERS HPEWKVLWSP
STRLGDRPSG TFSVVSHKEP MLSIANSYSK EELSEFFSRV EKSLGTSPRY TVELKIDGIA
VAIRYEDRVL VQALSRGNGK QGEDITSNIR TIRSLPLRLP EDAPEFIEVR GEVFFSYSTF
QIINEKQQQL EKTIFANPRN AAGGTLKLLS PQEVAKRKLE ISIYNLIAPG DNDSHYENLQ
RCLEWGFPVS GKPRLCSTPE EVISVLKTIE TERASLPMEI DGAVIKVDSL ASQRVLGATG
KHYRWALAYK YAPEEAETLL EDILVQVGRT GVLTPVAKLT PVLLSGSLVS RASLYNEDEI
HRKDIRIGDT VCVAKGGEVI PKVVRVCREK RPEGSEVWNM PEFCPVCHSH VVREEDRVSV
RCVNPECVAG AIEKIRFFVG RGALNIDHLG VKVITKLFEL GLVHTCADLF QLTTEDLMQI
PGIRERSARN ILESIEQAKH VDLDRFLVAL GIPLIGIGVA TVLAGHFETL DRVISATFEE
LLSLEGIGEK VAHAIAEYFS DSTHLNEIKK MQDLGVCISP YHKSGSTCFG KAFVITGTLE
GMSRLDAETA IRNCGGKVGS SVSKQTDYVV MGNNPGSKLE KARKLGVSIL DQEAFTNLIH
LE