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Description:
Probable endonuclease IV (EC 3.1.21.2) (Endodeoxyribonuclease IV).
Molecular weight: 32389
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
07-MAR-2006, entry version 41.
Phylogenetic order:
Bacteria Chlamydiae Chlamydiales Chlamydiaceae Chlamydophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein END4_CHLPN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001654 | AAD18871.1 | - |
| EMBL | AE002165 | AAF37910.1 | - |
| EMBL | BA000008 | BAA98939.1 | - |
| EMBL | AE017159 | AAP98689.1 | - |
| PIR | A86582 | A86582. | |
| PIR | H72042 | H72042. | |
| HSSP | P12638 | 1QUM | |
| GenomeReviews | AE002161_GR | CP0014.1 | |
| GenomeReviews | AE009440_GR | CpB0760.1 | |
| GenomeReviews | AE001363_GR | CPn0732.1 | |
| GenomeReviews | BA000008_GR | nfo.1 | |
| TIGR | CP0014 | -. | |
| BioCyc | CPNE115711:CP0014-MONOMER | -.1 | |
| BioCyc | CPNE115713:CPN0732-MONOMER | -.1 | |
| BioCyc | CPNE138677:CPJ0732-MONOMER | -.1 | |
| BioCyc | CPNE182082:CPB0760-MONOMER | -.1 | |
| HAMAP | MF_00152 | - | 1. |
| InterPro | IPR001719 | AP_endnuclease2. | |
| InterPro | IPR012307 | Xylisom_TIMbarrl. | |
| Pfam | PF01261 | AP_endonuc_2 | 1. |
| SMART | SM00518 | AP2Ec | 1. |
| TIGRFAMs | TIGR00587 | nfo | 1. |
| PROSITE | PS00729 | AP_NUCLEASE_F2_1 | 1. |
| PROSITE | PS00730 | AP_NUCLEASE_F2_2 | 1. |
| PROSITE | PS00731 | AP_NUCLEASE_F2_3 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Endonuclease; Hydrolase; Metal-binding; Nuclease; Zinc.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX MEDLINE=99206606; PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX MEDLINE=20150255; PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
RA White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
RA Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
RA Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
RA McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
RT pneumoniae AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX MEDLINE=20330349; PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138
RT from Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 293 Probable endonuclease IV.
/FTId=PRO_0000190833.
METAL 75 75 Zinc 1 (By similarity).
METAL 115 115 Zinc 1 (By similarity).
METAL 153 153 Zinc 1 (By similarity).
METAL 153 153 Zinc 2 (By similarity).
METAL 187 187 Zinc 2 (By similarity).
METAL 190 190 Zinc 3 (By similarity).
METAL 224 224 Zinc 2 (By similarity).
METAL 237 237 Zinc 3 (By similarity).
METAL 239 239 Zinc 3 (By similarity).
METAL 269 269 Zinc 2 (By similarity).
Comments:
-!- FUNCTION: Endonuclease IV plays a role in DNA repair. It cleaves
phosphodiester bonds at apurinic or apyrimidinic sites (AP sites)
to produce new 5' ends that are base-free deoxyribose 5-phosphate
residues. It preferentially attacks modified AP sites created by
bleomycin and neocarzinostatin (By similarity).
-!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-
phosphooligonucleotide end-products.
-!- COFACTOR: Binds 3 zinc ions (By similarity).
-!- SIMILARITY: Belongs to the AP endonuclease 2 family.
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Sequence length: 293
MKVLPPPSIP LLGAHTSTAG GLKNAIYEGR DIGASTVQIF TANQRQWQRR ALKEEVIEDF
KAALKETDLS YIMSHAGYLI NPGAPDPVIL EKSRIGIYQE ILDCITLGIS FVNFHPGAAL
KSSKEDCMNK IVSSFSQSAP LFDSSPPLVV LLETTAGQGT LIGSNFEELG YLVQNLKNQI
PIGVCVDTCH IFAAGYDITS PQGWEDVLNE FDEYVGLSYL RAFHLNDSMF PLGANKDRHA
PLGEGYIGKE SFKFLMTDER TRKIPKYLET PGGPENWQKE IGELLKFSKN RDS