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Description:
Exodeoxyribonuclease V beta chain (EC 3.1.11.5).
Molecular weight: 1210
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
11-JAN-2001, sequence version 2.
07-MAR-2006, entry version 36.
Phylogenetic order:
Bacteria Chlamydiae Chlamydiales Chlamydiaceae Chlamydophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein EX5B_CHLPN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001655 | AAD18877.1 | - |
| EMBL | AE002164 | AAF37903.1 | - |
| EMBL | BA000008 | BAA98945.1 | - |
| EMBL | AE017159 | AAP98695.1 | - |
| PIR | C81624 | C81624. | |
| PIR | G86582 | G86582. | |
| PIR | H72041 | H72041. | |
| HSSP | P09980 | 1UAA | |
| GenomeReviews | AE002161_GR | CP0007.1 | |
| GenomeReviews | AE009440_GR | CpB0767.1 | |
| GenomeReviews | AE001363_GR | CPn0738.1 | |
| GenomeReviews | BA000008_GR | recB.1 | |
| TIGR | CP0007 | -. | |
| BioCyc | CPNE115711:CP0007-MONOMER | -.1 | |
| BioCyc | CPNE115713:CPN0738-MONOMER | -.1 | |
| BioCyc | CPNE138677:CPJ0738-MONOMER | -.1 | |
| BioCyc | CPNE182082:CPB0767-MONOMER | -.1 | |
| InterPro | IPR004586 | RecB. | |
| InterPro | IPR000212 | UvrD-helicase. | |
| PANTHER | PTHR11070 | UvrD-helicase.1 | 1. |
| Pfam | PF00580 | UvrD-helicase | 1. |
| TIGRFAMs | TIGR00609 | recB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; Endonuclease; Exonuclease; Helicase; Hydrolase; Nuclease; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX MEDLINE=99206606; PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX MEDLINE=20150255; PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
RA White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
RA Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
RA Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
RA McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
RT pneumoniae AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX MEDLINE=20330349; PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138
RT from Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 1050 Exodeoxyribonuclease V beta chain.
/FTId=PRO_0000102044.
NP_BIND 21 28 ATP (Potential).
CONFLICT 142 142 N -> K (in Ref. 2).
CONFLICT 182 182 V -> I (in Ref. 1).
Comments:
-!- FUNCTION: Required for efficient DNA repair; it catalyzes the
unwinding of double-stranded DNA and the cleavage of single-
stranded DNA and it stimulates local genetic recombination. All of
these activities require concomitant hydrolysis of ATP (By
similarity).
-!- CATALYTIC ACTIVITY: Exonucleolytic cleavage (in the presence of
ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-
phosphooligonucleotides.
-!- SUBUNIT: Consist of three subunits; recB, recC and recD (By
similarity).
-!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
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Sequence length: 1050
MKPFNIFDSN SSIQGKFFLE ASAGTGKTFT IEQIVLRALI EGSLTHVEHA LAITFTNAST
NELKVRIKDN LAQTLRELKA VLNSQPASLP TYLDINCNVK QIYMQVRNAL ATLDQMSLFT
IHGFCNFVLE QYFPKTRLIH KNPALTHSQL VLHHITNYLK QDLWKNVLFQ EQFHLLAVRY
NVTSKHTSSL VDKLLASYTQ PISSYFSSRV ERLEQISLWH QQIYNSLLEI PKQVFLDQLT
AHISGFKKQP FSILDDLHHF VDLLYTSETH SSLFSFFKIA ETFNFKHRLA RYKPCAAFTV
LENMSWVERT LEFCNLDRIF NTLLVDLQEY LKQNYTPWLS PDESVFALEK LLSSSEAQPV
VQALREQYQL VLIDEFQDTD KQQWSIFSNL FISPKFTGSL FLIGDPKQSI YEWRSADLPT
YLTAKSSFSE DKQLQLVNNY RSTPKLMEAI NQIFGKISPF LEIPGYLPIE YHALNPQSSE
TFENPPHAPI HFFFYETIKD QALWIFSEAL RLQKEQKIPL GNMVVLVSDS NQAFELISYA
TIPVSFSKNK SIFHLTETHI LTTALLEAIL HPENYEKISK ILFSSLFGLS LDEVTTKKED
FTIYFQSLHS YISHHGLLAT FYRVMTTQGN VLFSSPRGDL IFQEMEKLCG YLDTISSYPY
HQLLHLKNFS ETGRWEEELA ISSYSEDLET LKITTIHSSK GLEYDIVFCP GIEKSKKNKS
SSELLREMYV ACTRAKKQLY LPISTQPPSL QRSSALTNYV KLEGTQSSAY DLAIHLHQEH
PDLFSYSLPK DHGHATTVLN LPLLETFALK VTPPKTIFSF SSTKFLLDTH KDSQSIPYSK
LPISKQQLPL GEKTGILIHK ILESIQFSLL QDTEYLMSTI MRFIKHTHLE GFEETILKLL
SKTFFSPLTF SSQTFSLSQV LPNKIFRETS FLFLENQELW QGVIDLFFEH EGKYYIIDWK
TSFLGETNSD YSKSNLSIYI KQEKLDYQGR IYVKAVRKFL NQFEIDDDVE LGVIFIRGID
TQGNGFFALN SSEDIPNFNP KAIQKCQAYH