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Description:
DNA mismatch repair protein mutL.
Molecular weight: 65001
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
07-MAR-2006, entry version 33.
Phylogenetic order:
Bacteria Chlamydiae Chlamydiales Chlamydiaceae Chlamydophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_CHLPN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001662 | AAD18950.1 | - |
| EMBL | AE002263 | AAF38832.1 | - |
| EMBL | BA000008 | BAA99020.1 | - |
| EMBL | AE017160 | AAP98770.1 | - |
| PIR | A72032 | A72032. | |
| PIR | B86592 | B86592. | |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE002161_GR | CP1059.1 | |
| GenomeReviews | AE009440_GR | CpB0841.1 | |
| GenomeReviews | AE001363_GR | CPn0812.1 | |
| GenomeReviews | BA000008_GR | mutL.1 | |
| TIGR | CP1059 | -. | |
| BioCyc | CPNE115711:CP1059-MONOMER | -.1 | |
| BioCyc | CPNE115713:CPN0812-MONOMER | -.1 | |
| BioCyc | CPNE138677:CPJ0812-MONOMER | -.1 | |
| BioCyc | CPNE182082:CPB0841-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX MEDLINE=99206606; PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX MEDLINE=20150255; PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
RA White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
RA Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
RA Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
RA McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
RT pneumoniae AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX MEDLINE=20330349; PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138
RT from Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 580 DNA mismatch repair protein mutL.
/FTId=PRO_0000177937.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 580
MSTRRPIQLL DPLTINQIAA GEVIENSVSV VKELIENSLD AGADEIEIET LGGGQGAIII
RDNGCGFRAE DIPIALQRHA TSKIREFSDI FSLNSFGFRG EALPSIASIS KMEIQSSIEG
DEGVRTVIHG GDIVSCEPCA RQLGTTVIVN SLFYNVPVRR GFQKSMQSDR LGIRKLIENR
ILSTANIGWS WISEGHHEIQ IAKQQGFQER VAYVMGDHFM QDALTIDKEA NGVRIVGVLG
SPSFHRPTRQ GQKIFINDRP IESLFISKKV GDAYALLLPL HRYPVFVLKL YLPSSWCDFN
VHPQKIEARI LKEELVGDCI KEAIVETLAC PPGILCRTHQ EIEESDSVPL PMFRMLETSD
VQEEESVEFD QNLFAYSSED VSLEKQEYTS RGPKSQMDWI YSSDVRFLTS LGRVVLAEDL
EGVHIIFTAA ARKHLFFLSL MQENSRMYQS QALLIPLRLQ VTPEEAFFFS HHGRTLCDLG
IEISQVGPCV FSIESTPTVI GEEELKEWLL LLAARGSTDI NSEALTALMK ETLTQATFSK
HQHVFDVSWL KLLWSVGKPE KGFDGARIRR LILDSDFMEG