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Description:
DNA mismatch repair protein mutS.
Molecular weight: 93211
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
11-JAN-2001, sequence version 2.
07-MAR-2006, entry version 36.
Phylogenetic order:
Bacteria Chlamydiae Chlamydiales Chlamydiaceae Chlamydophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_CHLPN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001673 | AAD19079.1 | - |
| EMBL | AE002251 | AAF38705.1 | - |
| EMBL | BA000008 | BAA99149.1 | - |
| EMBL | AE017160 | AAP98904.1 | - |
| PIR | C86608 | C86608. | |
| PIR | D81522 | D81522. | |
| PIR | G72017 | G72017. | |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AE002161_GR | CP0920.1 | |
| GenomeReviews | AE009440_GR | CpB0975.1 | |
| GenomeReviews | AE001363_GR | CPn0941.1 | |
| GenomeReviews | BA000008_GR | mutS.1 | |
| TIGR | CP0920 | -. | |
| BioCyc | CPNE115711:CP0920-MONOMER | -.1 | |
| BioCyc | CPNE115713:CPN0941-MONOMER | -.1 | |
| BioCyc | CPNE138677:CPJ0941-MONOMER | -.1 | |
| BioCyc | CPNE182082:CPB0975-MONOMER | -.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX MEDLINE=99206606; PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX MEDLINE=20150255; PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
RA White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
RA Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
RA Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
RA McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
RT pneumoniae AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX MEDLINE=20330349; PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138
RT from Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 828 DNA mismatch repair protein mutS.
/FTId=PRO_0000115085.
NP_BIND 624 631 ATP (Potential).
CONFLICT 579 579 R -> H (in Ref. 1).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 828
MTEKKPTPMM EQWHQCKEKA GDSVLLFRMG DFYEAFYDDA VLLSQHLELT LTQRQGIPMS
GIPVSTVDTY VDRLIGKGFK VAVAEQFGEP AKEKESKKIG PMARDIQRFV TPGTLLSSTL
LQEKFNNYIV AINRIGSLFG FACLDLSTGS FFIEECENTK ELVDEICRLA PSEVLSCNKF
YNKETAIVMQ LQQHLKLTLS TYADWAFEHK FASQKLTTHF QVASLDGFGL KGLVPAINAA
GGLLSYIQDK LLLPTKHIAI PQTRGKQQKL LIDTASQVNL ELLAPLNDPQ GKNSLLRIMD
HTSTPMGGRL LRQILISPFY NPKEILVRQD AVEFFLRQVT LRKNIKTYLC QVRDIERLMT
KVTTGLAGPR DIGTLRDSFS AGAQIYEQLA SATLPEFFID KCSLDTKLAS LIALLSKSLN
GDLPLRVSDG NIFVDEFHND LKRLRHNQEH SQEWIWEYQE RIRKETGIKK LKICFAQALG
YYIEVSSEFA PQLPKDFIRR QSRLHAERFT TIELQQFQDD MSNISEKLQT LETQFFKDLC
SHILQLRTEI LALSQSLADL DYIISLADLA HAQGYCRPRV DMSDTLCIYR GCHPVAKTLV
DTGKFIPNDT EMRGSQTRMI LLTGPNMAGK STYIRQIALL VIMAQMGSYI PAKSAHIGVI
DKIFTRIGAG DNLSKGMSTF MVEMAETANI LHNATDRSLV ILDEVGRGTS TYDGLAIAQA
VVEYLLFTDK KKAKTLFATH YKELTTLEDH CPHVENFHAG VKDKAGQPVF LYEILKGHSQ
KSFGIHVARL AGFPLCVVSR AQQILRQLEG PESITRPAQD KMQQLTLF