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Description:
Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-).
Molecular weight: 37398
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
11-JAN-2001, sequence version 2.
07-MAR-2006, entry version 40.
Phylogenetic order:
Bacteria Chlamydiae Chlamydiales Chlamydiaceae Chlamydophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVB_CHLPN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001623 | AAD18533.1 | - |
| EMBL | AE002198 | AAF38214.1 | - |
| EMBL | BA000008 | BAA98598.1 | - |
| EMBL | AE017158 | AAP98333.1 | - |
| PIR | A81586 | A81586. | |
| PIR | D72084 | D72084. | |
| PIR | D86539 | D86539. | |
| HSSP | Q56313 | 1J7K | |
| GenomeReviews | AE002161_GR | CP0365.1 | |
| GenomeReviews | AE009440_GR | CpB0402.1 | |
| GenomeReviews | AE001363_GR | CPn0390.1 | |
| GenomeReviews | BA000008_GR | ruvB.1 | |
| TIGR | CP0365 | -. | |
| BioCyc | CPNE115711:CP0365-MONOMER | -.1 | |
| BioCyc | CPNE115713:CPN0390-MONOMER | -.1 | |
| BioCyc | CPNE138677:CPJ0390-MONOMER | -.1 | |
| BioCyc | CPNE182082:CPB0402-MONOMER | -.1 | |
| HAMAP | MF_00016 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR004605 | RuvB. | |
| InterPro | IPR008823 | RuvB_C. | |
| InterPro | IPR008824 | RuvB_N. | |
| InterPro | IPR011991 | Wing_hlx_DNA_bd. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF05491 | RuvB_C | 1. |
| Pfam | PF05496 | RuvB_N | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00635 | ruvB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX MEDLINE=99206606; PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX MEDLINE=20150255; PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
RA White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
RA Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
RA Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
RA McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
RT pneumoniae AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX MEDLINE=20330349; PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138
RT from Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 337 Holliday junction ATP-dependent DNA
helicase ruvB.
/FTId=PRO_0000165515.
NP_BIND 57 64 ATP (Potential).
VARIANT 168 168 T -> A (in strain: CWL029 and TW-183).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing (By similarity).
-!- SUBUNIT: Forms a complex with ruvA (By similarity).
-!- SIMILARITY: Belongs to the ruvB family.
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Sequence length: 337
MTHQVAVLHQ DKKFDVSLRP KGLEEFYGQH HLKERLDLFL CAALQRGEVP GHCLFFGPPG
LGKTSLAHIV AYTVGKGLVL ASGPQLIKPS DLLGLLTSLQ EGDVFFIDEI HRMGKVAEEY
LYSAMEDFKV DITIDSGPGA RSVRVDLAPF TLVGATTRSG MLSEPLRTRF AFSARLSYYS
DQDLKEILVR SSHLLGIEAD SSALLEIAKR SRGTPRLANH LLRWVRDFAQ IREGNCINGD
VAEKALAMLL IDDWGLNEID IKLLTTIIDY YQGGPVGIKT LSVAVGEDIK TLEDVYEPFL
ILKGFIKKTP RGRMVTQLAY DHLKRHAKNL LSLGEGQ