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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 2016
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
07-MAR-2006, entry version 49.
Phylogenetic order:
Bacteria Chlamydiae Chlamydiales Chlamydiaceae Chlamydophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_CHLPN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001595 | AAD18249.1 | - |
| EMBL | AE002226 | AAF38489.1 | - |
| EMBL | BA000008 | BAA98306.1 | - |
| EMBL | AE017157 | AAP98029.1 | - |
| PIR | D72120 | D72120. | |
| PIR | H86502 | H86502. | |
| HSSP | P58301 | 1F2T | |
| GenomeReviews | AE002161_GR | CP0678.1 | |
| GenomeReviews | AE009440_GR | CpB0096.1 | |
| GenomeReviews | AE001363_GR | CPn0096.1 | |
| GenomeReviews | BA000008_GR | uvrA.1 | |
| TIGR | CP0678 | -. | |
| BioCyc | CPNE115711:CP0678-MONOMER | -.1 | |
| BioCyc | CPNE115713:CPN0096-MONOMER | -.1 | |
| BioCyc | CPNE182082:CPB0096-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 2. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | FALSE_NEG. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX MEDLINE=99206606; PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX MEDLINE=20150255; PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
RA White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
RA Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
RA Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
RA McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
RT pneumoniae AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX MEDLINE=20330349; PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138
RT from Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 1826 UvrABC system protein A.
/FTId=PRO_0000093043.
DOMAIN 1 581 ABC transporter 1.
DOMAIN 594 909 ABC transporter 2.
DOMAIN 1503 1814 ABC transporter 3.
NP_BIND 33 40 ATP 1 (Potential).
NP_BIND 626 633 ATP 2 (Potential).
ZN_FING 721 744 C4-type.
NP_BIND 966 973 ATP 3 (Potential).
NP_BIND 1536 1543 ATP 4 (Potential).
ZN_FING 1623 1649 C4-type.
CONFLICT 559 559 V -> G (in Ref. 3).
CONFLICT 1046 1046 K -> E (in Ref. 3).
CONFLICT 1066 1086 TTPQTIIDSLLKSYKDDYVTI -> IHLRPSSIATQSYNDE
LTSLL (in Ref. 3).
CONFLICT 1094 1094 S -> A (in Ref. 3).
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 3 ABC transporter domains.
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Sequence length: 1826
MKSLPVYVSG IKVRNLKNVS IHFNSEEIVL LTGVSGSGKS SIAFDTLYAA GRKRYISTLP
TFFATTITTL PNPKVEEIHG LSPTIAIKQN HFSHYSHATV GSTTELFSHL ALLFTLEGQA
RDPKTKEVLD LYSKEKVLST IMELSEGVQI SILAPLLRKD IAAIHEYAQQ GFTKVRCNGT
IHPIYSFLTS GIPEDCSVDI VIDTLIKSEN NIARLKVSLF TALEFGEGHC SVLSDEELMT
FSTKQQIDDV TYTPLTQQLF SPHALESRCS LCQGSGIFIS IDNPLLIDEN LSIKENCCSF
AGNCSSYLYH TIYQALADAL NFNLETPWKD LSPEIQNIFL RGKNNLVLPV RLFDQTLGKK
NLTYKVWRGV LNDIGDKVRY TTKPSRYLSK GMSAHSCSLC KGTGLGDYAS VATWEGKTFT
EFQQMSLNNW HVFFSKVKSP SLSIQEILQG LKQRLSFLID LGLGYLTPNR ALATLSGGEQ
ERTAIAKHLG GELFGITYIL DEPSIGLHPQ DTEKLIGVIK KLRDQGNTVI LVEHEERMIS
LADRIIDIGP GAGIFGGEVL FNGKPEDFLM NSSSLTAKYL RQELTIPIPE SREAPTSWLL
LTEATIHNLK NLSIRLPLAR LIGVTGVSGS GKSSLINNTL VPAIESFLKQ ENPKNLHFEW
GCIGRLIHIT RDLPGRSQRS IPLTYIKAFD DIRELFASQP RSLRQGLTKA HFSFNQPQGA
CIQCQGLGTM TISDDDTPIP CSECQGKRYH SEVLEILYEG KNIADILDMT AYEAEKFFIS
HPKIHEKIHA LCSLRLDYLP LGRPLSTLSG GEIQRLKLAH ELLFASPKQT LYVLDEPTTG
LHTHDIQALI EVLLSLTYLG HTVLVIEHNM HVVKVCDYVL ELGPEGGDLG GYLLASCTPK
DLIQLNTPTA KALAPYIEGS LDIPVVKSEP PSSPKSCDIL IKDAYQNNLK HIDLALPRNS
LIAIAGPGAS GKHSLVFDIL YASGNIAYAE LFPPYIRQGL LKETPLPSVG EVKGLSPVIS
VRKCSSSNRS YHTIASALGL SNGLEKLFAI LGEPFSPLTE EKLSKTTPQT IIDSLLKSYK
DDYVTITSPI PLGSDLEIFL QEKQKEGFIK LYSEGNLYDL DERLPLNLIE PAIVIQHTKV
SPKNSSSLLS AISVAFSLSS EIWIYISQKK QRKLSYSLGW KDKKGRLYPE ITHQLLSSDH
PEGRCLTCGG RGEILKISLE EHKEKIAHYT PLEFFSLFFP KSYMKPVQKL LKDENASQPL
KLLTTKEFLN FCRGSSEFPG MNALLMEQLD TESDSPLIKP LLALTSCPAC KGSGLNDYAN
YVRINNTSLL DIYQEDATFL ESFLNTIGTD DTRSIIQDLM NRLTFISKVG LSYITLGQRQ
DTLSDGENYR LHLAKKISIN LTNIVYLFEE PLSGLHPQDL PTIVQLLKEL VANNNTVIAT
DRSCSLIPHA DHAIFLGPGS GPQGGFLMDS DTEVCPSVDL HANVPQTEVC PKAPLSISKA
NHTRGSDRTL KVNLSIHHIQ NLKVSAPLHA LVAIGGVSGS GKTSLLLEGF KKQAELLIAK
GTTTFSDLVV IDSHPIASSQ RSDISTYFDI APSLRAFYAS LTQAKALNIS STMFSTNTKQ
GQCSDCQGLG YQWIDRAFYA LEKRPCPTCS GFRIQPLAQE VLYEGKHFGE LLHTPIETVA
LRFPFIKKIQ KPLKALLDIG LGYLPIGQKL SSLSVSEKTA LKTAYFLYQT PETPTLFLID
ELFSSLDPIK KQHLPEKLRS LINSGHSVIY IDHDVKLLKS ADYLIEIGPG SGKQGGKLLF
SGSPKDIYAS KDSLLKKYIC NEELDS