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Description:
UvrABC system protein B (Protein uvrB) (Excinuclease ABC subunit B).
Molecular weight: 74830
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
07-MAR-2006, entry version 39.
Phylogenetic order:
Bacteria Chlamydiae Chlamydiales Chlamydiaceae Chlamydophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRB_CHLPN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001661 | AAD18939.1 | - |
| EMBL | AE002263 | AAF38842.1 | - |
| EMBL | BA000008 | BAA99009.1 | - |
| EMBL | AE017160 | AAP98759.1 | - |
| PIR | B72034 | B72034. | |
| PIR | G86590 | G86590. | |
| HSSP | P56981 | 1D9X | |
| GenomeReviews | AE002161_GR | CP1070.1 | |
| GenomeReviews | AE009440_GR | CpB0830.1 | |
| GenomeReviews | AE001363_GR | CPn0801.1 | |
| GenomeReviews | BA000008_GR | uvrB.1 | |
| TIGR | CP1070 | -. | |
| BioCyc | CPNE115711:CP1070-MONOMER | -.1 | |
| BioCyc | CPNE115713:CPN0801-MONOMER | -.1 | |
| BioCyc | CPNE138677:CPJ0801-MONOMER | -.1 | |
| BioCyc | CPNE182082:CPB0830-MONOMER | -.1 | |
| HAMAP | MF_00204 | - | 1. |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR006935 | ResIII. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004807 | UvrB_ABC. | |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF04851 | ResIII | 1. |
| Pfam | PF02151 | UVR | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00631 | uvrb | 1. |
| PROSITE | PS50151 | UVR | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX MEDLINE=99206606; PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX MEDLINE=20150255; PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
RA White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
RA Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
RA Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
RA McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
RT pneumoniae AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX MEDLINE=20330349; PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138
RT from Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 657 UvrABC system protein B.
/FTId=PRO_0000138386.
DOMAIN 617 652 UVR.
NP_BIND 37 44 ATP (Potential).
MOTIF 90 113 Beta-hairpin.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. A damage recognition complex composed
of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon
binding of the uvrA(2)B(2) complex to a putative damaged site, the
DNA wraps around one uvrB monomer. DNA wrap is dependent on ATP
binding by uvrB and probably causes local melting of the DNA
helix, facilitating insertion of uvrB beta-hairpin between the DNA
strands. Then uvrB probes one DNA strand for the presence of a
lesion. If a lesion is found the uvrA subunits dissociate and the
uvrB-DNA preincision complex is formed. This complex is
subsequently bound by uvrC and the second uvrB is released. If no
lesion is found, the DNA wraps around the other uvrB subunit that
will check the other stand for damage (By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrA during the search for
lesions. Interacts with uvrC in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- DOMAIN: The beta-hairpin motif is involved in DNA binding (By
similarity).
-!- SIMILARITY: Belongs to the uvrB family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 657
MTFQLHAPFA PCGDQPEAIA RLSAGVRNQV KSQVLLGTTG SGKTFTIANV VANVNLPTLV
LAHNKTLAAQ LYQEFREFFP NNAVEYFISY YDYYQPEAYI ARSDTYIEKS LLINDEIDKL
RLSATRSILE RRDTLIVSSV SCIYGIGSPE NYTSMALVLE VGKEYPRNIL TAQLVKMHYQ
ASPIPQRSAF RERGSVIDIF PAYESELALR LEFLNDTLTS IEYSDPLTMI PKESVPSATL
YPGSHYVIPE AIREQAIRTI QEELEERMAF FDDRPIEKDR IFHRTTHDIE MIKEIGFCKG
IENYSRHFTG APPGAPPTCL LDYFPEDFLL IIDESHQTLP QIRAMYRGDQ SRKQSLVEYG
FRLPSAFDNR PLTYEEAQKY FRKVIYVSAT PGDTEVQESS GHIVQQIIRP TGIPDPMPEI
RPATGQVDDL LEEIRLRLSQ KHEKILVISI TKKLAEDMAG FLSELEIPAA YLHSGIETAE
RTQILTDLRS GVIDVLIGVN LLREGLDLPE VSLVAILDAD KEGFLRSTSS LIQFCGRAAR
NINGKVIFYA DQKTRSIEET LRETERRRQI QLDYNKEHNI VPKPIIKAIF ANPILQTSKD
SESPKESQRP LSKEDLEEQI KKYEALMQRA AKEFRFNEAA KYRDAMQACK EQLLYLF