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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 69426
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
07-MAR-2006, entry version 38.
Phylogenetic order:
Bacteria Chlamydiae Chlamydiales Chlamydiaceae Chlamydophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_CHLPN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001673 | AAD19078.1 | - |
| EMBL | AE002251 | AAF38706.1 | - |
| EMBL | BA000008 | BAA99148.1 | - |
| EMBL | AE017160 | AAP98903.1 | - |
| PIR | B86608 | B86608. | |
| PIR | F72017 | F72017. | |
| GenomeReviews | AE002161_GR | CP0921.1 | |
| GenomeReviews | AE009440_GR | CpB0974.1 | |
| GenomeReviews | AE001363_GR | CPn0940.1 | |
| GenomeReviews | BA000008_GR | uvrC.1 | |
| TIGR | CP0921 | -. | |
| BioCyc | CPNE115711:CP0921-MONOMER | -.1 | |
| BioCyc | CPNE115713:CPN0940-MONOMER | -.1 | |
| BioCyc | CPNE138677:CPJ0940-MONOMER | -.1 | |
| BioCyc | CPNE182082:CPB0974-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX MEDLINE=99206606; PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX MEDLINE=20150255; PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
RA White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
RA Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
RA Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
RA McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
RT pneumoniae AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX MEDLINE=20330349; PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138
RT from Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 603 UvrABC system protein C.
/FTId=PRO_0000138294.
DOMAIN 205 240 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 603
MRIEDFSLKL IPSSPGVYLM KDVHDQVLYI GKAKNLKNRL ASYFHEKGDS RERIPFLMKK
TASIETIVVS NETEALLLEN NLIKQHHPKY NVLLKDDKTF FCLAISLSHS WPKVEAIRTK
AITSSQRQLI FGPYVSAEAC HTLLEVISQW FPLRTCSDRE FALRKRPCIL YDMKRCLAPC
VGYCTPEEYQ GTLDKAILFL KGKIEEVVKD LEKVIQKASD NLEFEQAANY YRTLSLIKQA
MAKQQVEKFH FQNIDALGLY RHKQRTILTL LTVRSGKLLG ARHFSFFENA QEDQDLLSSF
ILQYYVSQPY IPKEILTPLP LEFPTLSYVL NAESPPRLRS PKTGYGKELL DLAYRNAKAY
AATTLPSSTL PYQDFQNILR MSQYPYRIEC YDNAHMQGAH ATGVYIVFEN NGFDPKQYRT
FSIDSEKTQN DLALLEEVLL RRFHSLTTAL PDMIVVDGGK THYNKTKKII QTLNLTGIQV
VTIAKEKSNH SRGLNKEKIF CETFPEGFSL PPTSNLLQFF QILRDEAHRF AISKHRKKRG
KALFEQEKIP GIGEVKRKRL LQKFKSWKQV MLSSQEELEA IPGLTKKDIA VLLARQKDFN
KSD