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Description:
DNA polymerase I (EC 2.7.7.7) (POL I).
Molecular weight: 10243
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
07-MAR-2006, entry version 39.
Phylogenetic order:
Bacteria Proteobacteria Epsilonproteobacteria Campylobacterales Helicobacteraceae Helicobacter.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DPO1_HELPJ:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001559 | AAD06938.1 | - |
| PIR | F71816 | F71816. | |
| HSSP | P19821 | 1CMW | |
| GenomeReviews | AE001439_GR | JHP1363.1 | |
| BioCyc | HPYL85963:JHP1363-MONOMER | -.1 | |
| InterPro | IPR002562 | 3_5_exonuclease. | |
| InterPro | IPR002421 | 5_3_exonuclease. | |
| InterPro | IPR001098 | DNA_pol. | |
| InterPro | IPR002298 | DNA_polI. | |
| InterPro | IPR000513 | Exo_N_I. | |
| InterPro | IPR008918 | HhH2. | |
| Pfam | PF01367 | 5_3_exonuc | 1. |
| Pfam | PF02739 | 5_3_exonuc_N | 1. |
| Pfam | PF00476 | DNA_pol_A | 1. |
| PRINTS | PR00868 | DNAPOLI. | |
| SMART | SM00474 | 35EXOc | 1. |
| SMART | SM00475 | 53EXOc | 1. |
| SMART | SM00279 | HhH2 | 1. |
| SMART | SM00482 | POLAc | 1. |
| TIGRFAMs | TIGR00593 | pola | 1. |
| PROSITE | PS00447 | DNA_POLYMERASE_A | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding; DNA-directed DNA polymerase; Exonuclease; Hydrolase; Nuclease; Nucleotidyltransferase; Transferase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=99120557; PubMed=9923682; DOI=10.1038/16495;
RA Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G.,
RA Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C.,
RA Gibson R., Merberg D., Mills S.D., Jiang Q., Taylor D.E., Vovis G.F.,
RA Trust T.J.;
RT "Genomic sequence comparison of two unrelated isolates of the human
RT gastric pathogen Helicobacter pylori.";
RL Nature 397:176-180(1999).
Feature:
CHAIN 1 897 DNA polymerase I.
/FTId=PRO_0000101242.
Comments:
-!- FUNCTION: In addition to polymerase activity, this DNA polymerase
exhibits 3' to 5' and 5' to 3' exonuclease activity (By
similarity).
-!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
diphosphate + DNA(n+1).
-!- SUBUNIT: Single-chain monomer with multiple functions.
-!- SIMILARITY: Belongs to the DNA polymerase type-A family.
-!- SIMILARITY: Contains 1 3'-5' exonuclease domain.
-!- SIMILARITY: Contains 1 5'-3' exonuclease domain.
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Sequence length: 897
MEQPVIKEGT LALIDTFAYL FRSYYMSAKN KPLTNDKGFP TGLLTGLVGM VKKFYKDRKN
MPFIVFALES QTKTKRAEKL GEYKQNRKDA PKEMLLQIPI ALEWLQKMGF TCVEVGGFEA
DDVIASLATL SPYKTRIYSK DKDFNQLLSD KIALFDGKTE FLAKDCVEKY GILPSQFTDY
QGIVGDSSDN YKGVKGIGSK NAKELLQRLG SLEKIYENLD LAKNLLSPKM YQALIQDKGS
AFLSKELATL ERGCIKEFDF LSCAFPSENP LLKIKDELKE YGFISTLRDL ENSPFIVENV
PILNSTPILD NTPALDNAPK KSRMIVLESA EPLSMFLEKL ENPNARVFMR LVLDKDKKIL
ALAFLLQDQG YFLPLEEALF SPFSLEFLQN AFSQMLQHAC IIGHDLKPLL SFLKAKYQVP
LENIRIQDTQ ILAFLKNPEK VGFDEVLKEY LKEDLIPHEK IKDFKTKSKA EKSELLSMEL
NALKRLCEYF EKGGLEEDLL TLARDIETPF VKVLMGMEFQ GFKIDAPYFK RLEQEFKNEL
NVLERQILDL IGVDFNLNSP KQLGEVLYDK LGLPKNKSHS TDEKNLLKIL DKHPSIPLIL
EYRELNKLFN TYTTPLLRLK DKDDKIHTTF IQTGTATGRL SSHSPNLQNI PVRSPKGLLI
RKGFIASSKE YCLLGVDYSQ IELRLLAHFS QDKDLMEAFL KGRDIHLETS KALFGEDLAK
EKRSIAKSIN FGLVYGMGSK KLSETLSIPL SEAKSYIEAY FKRFPSIKDY LNGMREEILK
TSKAFTLLGR YRVFDFTGVN DYVKGNYLRE GVNAIFQGSA SDLLKLGMLK VSERFKNNPS
VRLLLQVHDE LIFEIEEKNA PELQQEIQRI LNDEVYPLRV PLETSAFIAK RWNELKG