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Description:
Transcription-repair coupling factor (EC 3.6.1.-) (TRCF) (ATP-dependent helicase mfd).
Molecular weight: 1134
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
07-MAR-2006, entry version 35.
Phylogenetic order:
Bacteria Proteobacteria Epsilonproteobacteria Campylobacterales Helicobacteraceae Helicobacter.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MFD_HELPJ:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001567 | AAD07030.1 | - |
| PIR | E71806 | E71806. | |
| HSSP | Q9WY48 | 1GM5 | |
| GenomeReviews | AE001439_GR | JHP1458.1 | |
| BioCyc | HPYL85963:JHP1458-MONOMER | -.1 | |
| InterPro | IPR003711 | CarD_TRCF. | |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR004576 | Mfd. | |
| InterPro | IPR005118 | TRCF. | |
| Pfam | PF02559 | CarD_TRCF | 1. |
| Pfam | PF00270 | DEAD | 1. |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF03461 | TRCF | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00580 | mfd | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=99120557; PubMed=9923682; DOI=10.1038/16495;
RA Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G.,
RA Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C.,
RA Gibson R., Merberg D., Mills S.D., Jiang Q., Taylor D.E., Vovis G.F.,
RA Trust T.J.;
RT "Genomic sequence comparison of two unrelated isolates of the human
RT gastric pathogen Helicobacter pylori.";
RL Nature 397:176-180(1999).
Feature:
CHAIN 1 1001 Transcription-repair coupling factor.
/FTId=PRO_0000102169.
NP_BIND 512 519 ATP (Potential).
MOTIF 611 614 DEEH box.
Comments:
-!- FUNCTION: Necessary for strand-specific repair. A lesion in the
template strand blocks the RNA polymerase complex (RNAP). The
RNAP-DNA-RNA complex is specifically recognized by TRCF which
releases RNAP and the truncated transcript; the TCRF may replace
RNAP at the lesion site and then recruit the uvrA/B/C repair
system (By similarity).
-!- SIMILARITY: In the N-terminal section; belongs to the uvrB family.
-!- SIMILARITY: In the C-terminal section; belongs to the helicase
family. RecG subfamily.
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Sequence length: 1001
MIQSSLYRAL NKGFDYQILA CKDFKESELA KEVISYFKPN IKAVLFPELR AKKNDDLRSF
FEEFLQLLGG LREFYQALEN KQETIIIAPI SALLHPLPKK ELLESFKITL LEKYNLKDLK
DKLFYYGYEI LDLVEVEGEA SFRGDIVDIY IPNSKAYRLS FFDAECESIK ELDPATQMSL
KEDLLEIEIP PTLFSLDEPS YKDLKTKVEQ SPLNSFSKDL TSFGLWFLGE KANDLLGVYQ
SIISPRALEE IQELASLNEL DDERFKFLKV LENAQGYEDL EIHVHALEGF IALHSNRKIT
LLAPNKTILD NSISVLDAGN MECVIAPFVL NFKTPDRIFI SLNSFERKKK RQKSKLALNE
LNAGEWVVHD DYGVGVFSQL IQHSVLGSKR DFLEIAYLGE DKLLLPVENL HLIARYVVQS
DSVPVKDRLG KGSFLKLKAK VRAKLLEIAG KIIELAAERN LILGKKMDTH LAELEIFKSH
AGFEYTSDQE KAIAEISRDL SSHRVMDRLL SGDVGFGKTE VAMHAIFCAF LNGFQSALVV
PTTLLAHQHF ETLKARFENF GVKVARLDRY IKTSEKSKLL KAVELGLVDV LIGTHAILGT
KFKNLGLMVV DEEHKFGVKQ KEALKELSKS VHFLSMSATP IPRTLNMALS QIKGISSLKT
PPTDRKPSRT FLKEKNDELL KEIIYRELRR NGQIFYIHNH IASISKVKTK LEDLIPKLKI
AILHSQINAN ESEEIMLEFA KGNYQVLLCT SIVESGIHLP NANTIIIDNA QNFGLADLHQ
LRGRVGRGKK EGFCYFLIED QKSLNEQALK RLLALEKNSY LGSGESIAYH DLEIRGGGNL
LGQDQSGHIK NIGYALYTRM LEDAIYELSG GKKRLEKSVE IQLGVSAFLN PELIASDSLR
LDLYRRLSLC ENVDEVGQIH EEIEDRFGKM DDLSAQFLQI ITLKILANQL GILKLSNFNQ
NITLTYSDEK KESLKAPSKD DNDILETLLK HLHAQISLKR R