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Description:
ATP-dependent DNA helicase recG (EC 3.6.1.-).
Molecular weight: 71439
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
07-MAR-2006, entry version 35.
Phylogenetic order:
Bacteria Proteobacteria Epsilonproteobacteria Campylobacterales Helicobacteraceae Helicobacter.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECG_HELPJ:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001563 | AAD06990.1 | - |
| PIR | G71810 | G71810. | |
| HSSP | Q9WY48 | 1GM5 | |
| GenomeReviews | AE001439_GR | JHP1412.1 | |
| BioCyc | HPYL85963:JHP1412-MONOMER | -.1 | |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR004609 | RecG. | |
| Pfam | PF00270 | DEAD | 1. |
| Pfam | PF00271 | Helicase_C | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00643 | recG | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=99120557; PubMed=9923682; DOI=10.1038/16495;
RA Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G.,
RA Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C.,
RA Gibson R., Merberg D., Mills S.D., Jiang Q., Taylor D.E., Vovis G.F.,
RA Trust T.J.;
RT "Genomic sequence comparison of two unrelated isolates of the human
RT gastric pathogen Helicobacter pylori.";
RL Nature 397:176-180(1999).
Feature:
CHAIN 1 623 ATP-dependent DNA helicase recG.
/FTId=PRO_0000102144.
NP_BIND 259 266 ATP (Potential).
MOTIF 353 356 DEQH box.
Comments:
-!- FUNCTION: Critical role in recombination and DNA repair. Help
process Holliday junction intermediates to mature products by
catalyzing branch migration. Has a DNA unwinding activity
characteristic of a DNA helicase with a 3' to 5' polarity. RecG
unwind branched duplex DNA (Y-DNA) (By similarity).
-!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
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Sequence length: 623
MQETDDLLKT LNVKSLLEAL LVYTPKGYKD LSLLERFETG LSGVLEVGIL EKKNYAKVLK
IFAYSKRFYK NLELVFFNHS AFYYNQFKTG ESLFIYGKLE QSSFNQAYII NTPKILTEFG
KISLIFKKVK NHKKIQENLQ KLLSLENLKK EGVKENVARL LLEIFFPTPH FVKDFETNKN
FPSQHLNALK YIEMLFYMKN LERKKLQFNA KIACPNNSER LKAFIASLPF KLTRDQQNAI
KEIQSDLTSP IACKRLIIGD VGCGKTMVIL ASMVLAYPNK TLLMAPTSIL AKQLYHEALK
FLPPYFEVEL LLGGSHKKRS NHLFEKITHV VIGTQALLFD KRDLNEFALV ITDEQHRFGT
KQRYQLEKMA SSKGNKPHSL QFSATPIPRT LALAKSAFVK TTMIREIPYP KEIETLVLHK
REFKIVMEKI SEEIAKNHQV IVVYPLVNKS EKIPYLSLSE GASFWQKRFK NIYTTSGQDK
NKEEVIEEFR ELGSILLATT LIEVGISLPR LSVIVILAPE RLGLATLHQL RGRVSRNGLK
GYCFLCTIQE ENERLEKFAD ELDGFKIAEL DLQYRKSGDL LQGGKQSGNS FEYIDLARDE
NIIAEVKQDF LKNASVSQGT FEN