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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10474
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
07-MAR-2006, entry version 38.
Phylogenetic order:
Bacteria Proteobacteria Epsilonproteobacteria Campylobacterales Helicobacteraceae Helicobacter.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_HELPJ:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001496 | AAD06222.1 | - |
| PIR | H71906 | H71906. | |
| HSSP | P58301 | 1F2T | |
| GenomeReviews | AE001439_GR | JHP0644.1 | |
| BioCyc | HPYL85963:JHP0644-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 2. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=99120557; PubMed=9923682; DOI=10.1038/16495;
RA Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G.,
RA Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C.,
RA Gibson R., Merberg D., Mills S.D., Jiang Q., Taylor D.E., Vovis G.F.,
RA Trust T.J.;
RT "Genomic sequence comparison of two unrelated isolates of the human
RT gastric pathogen Helicobacter pylori.";
RL Nature 397:176-180(1999).
Feature:
CHAIN 1 941 UvrABC system protein A.
/FTId=PRO_0000093055.
DOMAIN 268 592 ABC transporter 1.
DOMAIN 604 934 ABC transporter 2.
NP_BIND 37 44 ATP (Potential).
ZN_FING 260 287 C4-type.
NP_BIND 637 644 ATP (Potential).
ZN_FING 737 763 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 941
MQHKTIMDKI IIQGARENNL KNIFLEIPKN QFVVFTGLSG SGKSTLAFDT LYAEGQRRYL
ESLSSYARQF LDKVGKPNVD KIEGLTPAIA IDQKTTSKNP RSTVGTITEI YDYLRLLFAR
VGEQFCPTCL EPISSMSASD IISQICHLEE NSKIIILAPI IKDKKGSFND KLESLRLKGY
VRAFVDGVMV RLDEEIHLHK TKKHTIEAVV DRVVINSENA SRIASAVEKA LKESYGELEV
EILQDNAPSI RKHYSEHKAC FKCKMSFEEL EPLSFSFNSP KGACESCLGL GTKFSLDISK
ILDPNTPLNQ GAIKVIFGYN RSYYAQMFEG FCTYNGIDSA LCFNELNKEQ QDALLYGNGT
EISFHFKNSP LKRPWKGIIQ IAYDMFKEQK DLSDYMSEKT CSSCNGHRLK ASSLSVQVAG
LKMADFLTKP IEEVYHFFND PTHFNYLNEQ EKKIAEPILK EILERVFFLY DVGLGYLTLG
RDARTISGGE SQRIRIASQI GSGLTGVLYV LDEPSIGLHE KDTLKLINTL RNLQKKGNTL
IVVEHDKETI KHADFVVDIG PKAGRHGGEV VFSGSVKDLL QNNHSTALYL NGTKKIERPK
FEPPKEKHFL EIKNVNINNI KNLSVQIPLK QLVCITGVSG SGKSSLILQT LLPTAQTLLN
HAKKNQSLNG VEIVGLEYLD KVIYLDQAPI GKTPRSNPAT YTGVMDEIRI LFAEQKEAKI
LGYSTSRFSF NVKGGRCEKC QGDGDIKIEM HFLPDVLVQC DSCKGAKYNP QTLEIKVKGK
SIADVLNMSV EEAYEFFAKF PKIAVKLKTL IDVGLGYITL GQNATTLSGG EAQRIKLAKE
LSKKDTGKTL YILDEPTTGL HFEDVNHLLQ VLHSLVALGN SMLVIEHNLD IIKNADYIID
MGPDGGDKGG KVIASGTPLE VAQNCEKTQS YTGKFLALEL K