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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 68672
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
07-MAR-2006, entry version 34.
Phylogenetic order:
Bacteria Proteobacteria Epsilonproteobacteria Campylobacterales Helicobacteraceae Helicobacter.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_HELPJ:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001506 | AAD06337.1 | - |
| PIR | B71893 | B71893. | |
| HSSP | P13299 | 1MK0 | |
| GenomeReviews | AE001439_GR | JHP0760.1 | |
| BioCyc | HPYL85963:JHP0760-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=99120557; PubMed=9923682; DOI=10.1038/16495;
RA Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G.,
RA Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C.,
RA Gibson R., Merberg D., Mills S.D., Jiang Q., Taylor D.E., Vovis G.F.,
RA Trust T.J.;
RT "Genomic sequence comparison of two unrelated isolates of the human
RT gastric pathogen Helicobacter pylori.";
RL Nature 397:176-180(1999).
Feature:
CHAIN 1 594 UvrABC system protein C.
/FTId=PRO_0000138306.
DOMAIN 205 240 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 594
MADLLSSLKN LSSSSGVYQY FDKNRQLLYI GKAKNLKKRI KSYFSVRNNE ITPNPRTSLR
VQMMVKQIAF LETILVENEQ DALILENSLI KQLKPKYNIL LRDDKTYPYI YMDFSIDFPI
PLITRKILKQ PGVKYFGPFT SGAKDILDSL YELLPLVQKK NCIKDKKACM FYQIERCKAP
CEDKITKEEY LKIAKECLEM IENKDRLIKE LELKMERLSS NLRFEEALIY RDRIAKIQKI
APFTCMDLAK LYDLDIFAFY GGNNKAVLVK MFMRGGKIIS SAFEKIHSLN GFDTDEAMKQ
AIINHYQSHL PLMPEQILLS ACSNETLKEL QEFISHQYSK KIALSIPKKG DKLALIEIAM
KNAQEIFSQE KTSNEDRILE EARSLFNLEC VPYRVEIFDT SHHSNSQCVG GMVVYENNAF
QKDSYRRYHL KGSNEYDQMS ELLTRRALDF AKEPPPNLWV IDGGRAQLNI ALEILKSSGS
FVEVIAISKE KRDSKAYRSK GGAKDIIHTI SHTFKLLPSD KRLQWVQKLR DESHRYAINF
HRSTKLKNMK QIALLKEKGI GEASVKKLLD YFGSFEAIEK ASDQEKNAVL KKRK