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Description:
DNA mismatch repair protein mutL.
Molecular weight: 71219
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
07-MAR-2006, entry version 26.
Phylogenetic order:
Bacteria Firmicutes Bacillales Bacillaceae Bacillus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_BACHD:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000004 | BAB06087.1 | - |
| PIR | H83945 | H83945. | |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | BA000004_GR | BH2368.1 | |
| BioCyc | BHAL86665:BH2368-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C-125 / JCM 9153;
RX MEDLINE=20512582; PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N.,
RA Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S.,
RA Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus
RT halodurans and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
Feature:
CHAIN 1 637 DNA mismatch repair protein mutL.
/FTId=PRO_0000177926.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 637
MAKIIKLDDH LSNKIAAGEV VERPASVVKE LVENALDANS RKITIEVEAG GLDRIRVIDD
GDGIEREDVE TAFFRHATSK IKTDKDLFQI ATLGFRGEAL PSIASVSHVQ IKTSTGGDGG
TEMVLEGGVI KKIGSTAMGK GTDLTVTQLF YNTPARLKYV KTVHTELGNI SDVVNRLALA
HPYVSFQLFH NGKNVLRTSG NGDQLQVIAA IYGRTVAKQM VPLSGETIDF TVSGFAAKPE
VTRASRQYMS LLVNGRYIRN VALSKAIQQG FHTLLPIGRY PIAIVNIELD PQLIDVNVHP
SKLEVRVSKE EELCRLVTET IERAFKKEQL IPEATKPTGG KQKSEQLSFT LDDFTSAKPS
EDRGSTSSNE ENEQRSSIDK NVLFQEERKL SNDLPSINMV REASASVEPA LEKEPPAAEL
TAGAKGAMEQ ASMEEETSNS LPANRVPTMY PIGQMHGTYI LAQNDQGLYI IDQHAAQERM
KYEYFREKVG EVTNELQELI VPITVECTLQ EAAYIEEHLE DLKQVGLFFE EFGPQTFMIR
QHPTWFPKGL EEETIREMID QLMEKRKVDI KKLREEVAIL MSCKAAIKAN RHLRHDEMYA
LLEALRKSSD PFTCPHGRPI IVQITTYEME KMFKRVM