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Description:
DNA mismatch repair protein mutS.
Molecular weight: 98368
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
07-MAR-2006, entry version 28.
Phylogenetic order:
Bacteria Firmicutes Bacillales Bacillaceae Bacillus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_BACHD:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000004 | BAB06088.1 | - |
| PIR | A83946 | A83946. | |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | BA000004_GR | BH2369.1 | |
| BioCyc | BHAL86665:BH2369-MONOMER | -.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C-125 / JCM 9153;
RX MEDLINE=20512582; PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N.,
RA Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S.,
RA Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus
RT halodurans and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
Feature:
CHAIN 1 865 DNA mismatch repair protein mutS.
/FTId=PRO_0000115069.
NP_BIND 605 612 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 865
MALQTPMMKQ YLEIKAQYKD AFLFFRLGDF YELFLDDAVK AAQELEITLT GRGKGEERIP
MCGVPYHSAD HYISRLLEKG YKIAICEQVE DPKNAKGVVK REVIKLITPG TIMDGKLIVE
KENNFLCAVT RFEDQSYGIA RADLTTGESR VSLVSEQDDL FHELASSSIK EVVLSPGWTE
EDAHRLRQSL SVTLSEEEAE DLPKGYESLC ENVEQPKLLR AFGRLLQYLL RTQKRSLEHL
QPVQYDPPNE VMKIDLHSRR NLELVETLRE KKKKGSLLWA VDETVTAMGG RLLKQWVERP
LLSKKEIERR QGLVQSFLDH YFEREELRDE LRHVYDLERL VGKVAYGNVN ARELVQLRKS
LQRIPAIFAL VEKIGNQDVN ERLQTIDRCE SLVDLLEHSL VDDPPVSIKE GGMIRDGFHK
ELDTYRDASR NGKSWIAELE QKEREATGIK SLKIGYNKVF GYYIEVTKAN IHLLEEGRYE
RKQTLTNAER YVTPELKEKE ALILNAEESI VQLEYDLFLQ VREQVKDYIR PLQALAQMIS
ELDVIQGFAT VSETHHYVRP ALQEDRAIAI KGGRHPVVER VIPNGEYVAN DVDMKDGRSI
LLITGPNMAG KSTYMRQLAL IAIMGQIGCF VPADEARLPI FDQVFTRIGA ADDLASGQST
FMVEMLETKY ALQKATQNSL ILLDEIGRGT STYDGMALAQ AIIEYIHDEI RAKTLFSTHY
HELTALEKEL SDVKNVHVSA VEEQGTVVFL HKVVDGQADR SYGIYVAELA GLPNVVTERA
ETLLAELEGE KEIVASEKEV ASTNEPTQLS LFEPEPLEAY KPKGNKQPLS DEEKTVLHDL
QSVDVLNTTP LEAIRLLNQW QQKLR