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Description:
Holliday junction ATP-dependent DNA helicase ruvA (EC 3.6.1.-).
Molecular weight: 23181
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
07-MAR-2006, entry version 34.
Phylogenetic order:
Bacteria Firmicutes Bacillales Bacillaceae Bacillus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVA_BACHD:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000004 | BAB04943.1 | - |
| PIR | H83802 | H83802. | |
| HSSP | P08576 | 1CUK | |
| GenomeReviews | BA000004_GR | BH1224.1 | |
| BioCyc | BHAL86665:BH1224-MONOMER | -.1 | |
| HAMAP | MF_00031 | - | 1. |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR012340 | OB_NA_bd_sub. | |
| InterPro | IPR000085 | RuvA. | |
| InterPro | IPR011114 | RuvA_C. | |
| Pfam | PF07499 | RuvA_C | 1. |
| Pfam | PF01330 | RuvA_N | 1. |
| ProDom | PD006268 | RuvA | 1. |
| SMART | SM00278 | HhH1 | 2. |
| TIGRFAMs | TIGR00084 | ruvA | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C-125 / JCM 9153;
RX MEDLINE=20512582; PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N.,
RA Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S.,
RA Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus
RT halodurans and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
Feature:
CHAIN 1 203 Holliday junction ATP-dependent DNA
helicase ruvA.
/FTId=PRO_0000094601.
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing. RuvA stimulates, in the presence of DNA, the weak
ATPase activity of ruvB (By similarity).
-!- SUBUNIT: Forms a complex with ruvB.
-!- SIMILARITY: Belongs to the ruvA family.
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Sequence length: 203
MIDYLRGTLT DIDHQYAVVE VHGVGYQVYC PNPYEFEKER DSVITIYTFQ YVREDVIRLY
GFRTKEKRSL FEKLLNVSGI GPKGALAILA TGQPEHVIQA IEEEDEAFLV KFPGVGKKTA
RQIILDLKGK VDELHPGLFS QKEEQPKPHE KNDGNQALDE AMEALKALGY VEKELKKVKP
KLEQETLTTD AYIKKALQLM LNR