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Description:
Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-).
Molecular weight: 37350
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
03-APR-2002, integrated into UniProtKB/Swiss-Prot.
03-APR-2002, sequence version 2.
07-MAR-2006, entry version 30.
Phylogenetic order:
Bacteria Firmicutes Bacillales Bacillaceae Bacillus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVB_BACHD:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000004 | BAB04944.1 | ALT_INIT |
| PIR | A83803 | A83803. | |
| HSSP | Q56313 | 1J7K | |
| GenomeReviews | BA000004_GR | BH1225.1 | |
| BioCyc | BHAL86665:BH1225-MONOMER | -.1 | |
| HAMAP | MF_00016 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR004605 | RuvB. | |
| InterPro | IPR008823 | RuvB_C. | |
| InterPro | IPR008824 | RuvB_N. | |
| InterPro | IPR011991 | Wing_hlx_DNA_bd. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF05491 | RuvB_C | 1. |
| Pfam | PF05496 | RuvB_N | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00635 | ruvB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C-125 / JCM 9153;
RX MEDLINE=20512582; PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N.,
RA Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S.,
RA Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus
RT halodurans and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
Feature:
CHAIN 1 333 Holliday junction ATP-dependent DNA
helicase ruvB.
/FTId=PRO_0000165489.
NP_BIND 60 67 ATP (Potential).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing (By similarity).
-!- SUBUNIT: Forms a complex with ruvA (By similarity).
-!- SIMILARITY: Belongs to the ruvB family.
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Sequence length: 333
MEERMVSAEA QTEEAAVEQG IRPHSFEQYI GQEKVKQNLK VFIEAAKMRE EALDHVLLYG
PPGLGKTTLS TIIANELGVQ MRTTSGPAIE RPGDLAAILT ALEPGDVLFI DEIHRLNRMV
EEVLYPAMED YCIDIVIGKG PTARSVRLDL PPFTLVGATT RAGMLSSPLR DRFGVMARLE
YYNVEELTTI IERTATIFDT ELERDASIEI ARRSRGTPRI ANRLLRRVRD FAQVSGDMRI
SSSRAIESLE RLQVDRLGLD HIDHKLIKGI MTKFNGGPVG LETISATIGE ETDTIEEVYE
PYLLQIGFLQ RTPRGRVVTP LAYEHFNMEV PNK