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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10644
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
07-MAR-2006, entry version 34.
Phylogenetic order:
Bacteria Firmicutes Bacillales Bacillaceae Bacillus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_BACHD:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000004 | BAB07313.1 | - |
| PIR | B84099 | B84099. | |
| GenomeReviews | BA000004_GR | BH3594.1 | |
| BioCyc | BHAL86665:BH3594-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C-125 / JCM 9153;
RX MEDLINE=20512582; PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N.,
RA Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S.,
RA Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus
RT halodurans and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
Feature:
CHAIN 1 957 UvrABC system protein A.
/FTId=PRO_0000093034.
DOMAIN 315 593 ABC transporter 1.
DOMAIN 605 935 ABC transporter 2.
NP_BIND 33 40 ATP (Potential).
ZN_FING 252 279 C4-type.
NP_BIND 639 646 ATP (Potential).
ZN_FING 738 764 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 957
MGLDNIVVKG ARSHNLKNID VTIPRDKLVV LTGLSGSGKS SLAFDTIYAE GQRRYVESLS
AYARQFLGQM DKPDVDSIEG LSPAISIDQK TTSRNPRSTV GTVTEIFDYL RLLYARIGKP
VCPKHGIEIS SQTVQQMVDR ILSYEERTKL QILAPLVSGR KGTHVKVLED IKKQGFVRVR
IDGEMREVAE EIELDKNKKH TIEVVIDRIV VKEGIETRLA DSLETALQLA DGRVVVDIIG
KEELLFSQHH ACPQCGFSIP ELEPRMFSFN SPFGACPTCD GLGVKLEVDL ELVIPDRSRT
LSENAIAPWE PISSQYYPQM LEAVCNHYGI DMDTPVEQLP DHQLEKILYG SGHEKIFFRY
ENDLGQVREN EILFEGVIPN VKRRYHETSS DYIRDQLEAY MAQKACPTCK GHRLKKEALA
VLIGGKHLGE VTKLSIKEAK TFFESLELSK KDFSIARLIL KEINDRLGFL MNVGLDYLTL
SRSAGTLSGG EAQRIRLATQ IGSSLMGVLY ILDEPSIGLH QRDNDRLIST LAHMRDLGNT
LIVVEHDEDT MLAADYIIDI GPGAGVHGGQ VTAAGSPEEI MNDAKSLTGQ YLSGKKFIPI
PSERRQPNGR SFTVKGASEN NLKQVNVEFP LGVFIAVTGV SGSGKSTLIN EIVHKALAQK
LHRAKDKPGK HKEIVGIEHV DKVIDIDQSP IGRTPRSNPA TYTGVFDDIR DVFAMTNEAK
VRGYKKGRFS FNVKGGRCEA CRGDGIIKIE MHFLPDVYVP CEVCHGKRYN RETLDITYKG
KTIADVLDMT VEEALEFFTN IPRIKRKIQT LVDVGLGYIK LGQPATTLSG GEAQRVKLAS
QLHKRATGKT LYILDEPTTG LHVDDIDRLL KVLQRIVDNG DTVLVIEHNL DVIKTVDHII
DLGPEGGDKG GTIVAQGTPE EVVEVEGSYT GKYLRPILER DRKRMDSRIR EHELQRS