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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 68177
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
07-MAR-2006, entry version 29.
Phylogenetic order:
Bacteria Firmicutes Bacillales Bacillaceae Bacillus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_BACHD:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000004 | BAB06816.1 | - |
| PIR | A84037 | A84037. | |
| SMR | Q9K8A9 | 3-97.1 | |
| GenomeReviews | BA000004_GR | BH3097.1 | |
| BioCyc | BHAL86665:BH3097-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C-125 / JCM 9153;
RX MEDLINE=20512582; PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N.,
RA Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S.,
RA Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus
RT halodurans and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
Feature:
CHAIN 1 591 UvrABC system protein C.
/FTId=PRO_0000138287.
DOMAIN 196 231 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 591
MKDHIKQKLT VLPDQPGCYL MKDRQGTIIY VGKAKVLKNR VRSYFTGSHD AKTQRLVGEI
ADFEYIVTSS NIEALILEMN LIKKHDPKYN VMLKDDKSYP YLKLTNEEHP RLVTTRKLKK
DGGKYFGPYP NAGAANETKK LLDRLYPLRK CRTLPDKVCL YYHIGQCLAP CVYEVTPEQN
EQMVQEITRF LKYGHKEVKV ELEKKMHKAA EELNFERAKE LRDTLGYMEA VMEKQTMMVN
DRVDRDVFGY AYDKGWMCVQ VFFVRQGKLI ERDVSIFPFY KEAEEDFLTF IGQFYLQKDH
IKPGEVLLPA GTDAALVEQL LDVSVHIPKR GKKKELVDVA MRNATMALKE KFALIERNEE
RTIKAVEQLG EAMGIPTPYR IEAFDNSNIQ GTDPVSAMVA FIDGKPNKKE YRKYKIKTVT
GPDDYESMRE VVRRRYVRLL KEQRSLPDLI VIDGGKGQIA AAQEILHDEL GLSIPVCGLA
KDEKHRTSQL LLGDPPQVVP LKRDSHEFYL LQRIQDEVHR FALTFHRQTR SKTFFQSVLD
DVPGIGEKRK RQLLKHFGSV KKMKEASIDD FLALSIPKSV AETLYNKLQT K