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Description:
UV DNA damage endonuclease (EC 3.-.-.-) (UV-endonuclease) (UVED).
Molecular weight: 36900
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 ) pyrimidine dimer repair( GO:0006290 )
Important dates:
06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Firmicutes Bacillales Bacillaceae Bacillus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVSE_BACHD:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000004 | BAB06316.1 | - |
| PIR | E83974 | E83974. | |
| GenomeReviews | BA000004_GR | BH2597.1 | |
| BioCyc | BHAL86665:BH2597-MONOMER | -.1 | |
| HAMAP | MF_00606 | - | 1. |
| InterPro | IPR004601 | UvdE. | |
| Pfam | PF03851 | UvdE | 1. |
| TIGRFAMs | TIGR00629 | uvde | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C-125 / JCM 9153;
RX MEDLINE=20512582; PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N.,
RA Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S.,
RA Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus
RT halodurans and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
Feature:
CHAIN 1 322 UV DNA damage endonuclease.
/FTId=PRO_0000215033.
Comments:
-!- FUNCTION: Component in a DNA repair pathway. Removal of UV-light
damaged nucleotides. Recognizes pyrimidine dimers and cleave a
phosphodiester bond immediately 5' to the lesion (By similarity).
-!- SIMILARITY: Belongs to the uve1/uvsE family.
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Sequence length: 322
MRIQFGYVAM SMELANASPS KTMTATQFEK IEDHEAGLRK LERIAKTNLH NCLRLLKHNL
AYQISFFRLS SKLVPLVNHP LTEGWKYELA IAEELQAVGE FASEHQMRID FHPDHFVVLN
SEAKEITRRS LQTLLYHYKL LKGMEIDPRH RCVLHVGGKK KGVEAGLEQF IENTASIPKS
LLSMIMLEND DKSYTIDDVL YLGEKLAIPV VLDIHHHDVL HRSKSLQETW QRIVATWEDS
PLPVKIHLSS PLSGEDDPRH HDYINADRFI AFLHEIGADA VDHLHVMIEA KKKDLALFQL
MKDLAEYDEI TVVSKSAVEF NP