Description:
DNA mismatch repair protein mutS.
Molecular weight: 98876
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Xanthomonadales Xanthomonadaceae Xanthomonas.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_XANAC:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE011760 | AAM36174.1 | - |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AE008923_GR | XAC1303.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=306 / ATCC 13902 / XV 101;
RX MEDLINE=22022145; PubMed=12024217; DOI=10.1038/417459a;
RA da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R.,
RA Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A.,
RA Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C.,
RA Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F.,
RA Ciapina L.P., Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R.,
RA El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C.,
RA Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A.,
RA Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F.,
RA Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M.,
RA Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H.,
RA Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R.,
RA Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F.,
RA Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D.,
RA Trindade dos Santos M., Truffi D., Tsai S.M., White F.F.,
RA Setubal J.C., Kitajima J.P.;
RT "Comparison of the genomes of two Xanthomonas pathogens with differing
RT host specificities.";
RL Nature 417:459-463(2002).
Feature:
CHAIN 1 902 DNA mismatch repair protein mutS.
/FTId=PRO_0000115169.
NP_BIND 654 661 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 902
MGRRNRRATR HGESSKSALI DCHIPEEHFL QSTDPKEKTK NAGGAVEHTP LMKQFFAAKS
DYPDLLLFFR MGDFYELFYD DARKAARLLD ITLTQRGSSG GAPIPMAGVP VHAYEGYLAR
LVALGESVAI CEQIGDPALA KGLVERKVVR IVTPGTVTDE ALLDERRDTL LMAISRSKQG
YGLAWADLAG GRFLVNEVDS ADALEAEIAR LEPAELLVPD EDNWPEFLRG RIGVRRRPPW
LFDADSGRRQ LLAFFKLHDL SGFGIDDKPC ATAAAGALLG YVEETQKQRL PHLTSIAMEV
ASEAISMNAA TRRHLELDTR VDGDTRNTLL GVLDSTVTPM GGRLLRRWLH RPLRLRDVLV
QRHHAVGTLI DAAADADLRE AFRALGDLER ILTRVALRSA RPRDFSTLRD GLALLPKVRA
ILAPLDSPRL QALHAELGEH DATAHLLISA VAETPPLKLS DGGVIATGYD ADLDELRRLS
TNADQFLIDL EQRERASSGI ATLKVGYNRV HGYYIEISKG QAEKAPLHYS RRQTLTNAER
YITEELKSFE DKVLSARERS LSREKLLYEG LLDALGTELE GLKRCAGALS ELDVLAGFAE
RAQALDWSQP ELDSAPCLRI ERGRHPVVEA VREQPFEPND LDLHSDRRML VITGPNMGGK
STYMRQNALI VLLAHIGSYV PASRAVIGPI DRILTRIGAG DDLARGQSTF MVEMAETSYI
LHHATPQSLV LMDEIGRGTS TYDGLALADA VARHLAQTNR CYTLFATHYF ELTALADASH
AGGASGIANV HLDAVEHGER LVFMHAVKDG PANRSFGLQV AALAGLPKAA VTQARRRLAE
LEQRGGESHS AQMAPTALDA PQQFGLFTAP SSAAQEALQA LDPDELTPKQ ALEALYRLKA
LL