Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 26769
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
07-MAR-2006, entry version 25.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Xanthomonadales Xanthomonadaceae Xanthomonas.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_XANAC:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE012031 | AAM38667.1 | - |
| HSSP | P12295 | 1FLZ | |
| GenomeReviews | AE008923_GR | XAC3825.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=306 / ATCC 13902 / XV 101;
RX MEDLINE=22022145; PubMed=12024217; DOI=10.1038/417459a;
RA da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R.,
RA Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A.,
RA Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C.,
RA Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F.,
RA Ciapina L.P., Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R.,
RA El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C.,
RA Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A.,
RA Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F.,
RA Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M.,
RA Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H.,
RA Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R.,
RA Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F.,
RA Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D.,
RA Trindade dos Santos M., Truffi D., Tsai S.M., White F.F.,
RA Setubal J.C., Kitajima J.P.;
RT "Comparison of the genomes of two Xanthomonas pathogens with differing
RT host specificities.";
RL Nature 417:459-463(2002).
Feature:
CHAIN 1 241 Uracil-DNA glycosylase.
/FTId=PRO_0000176166.
ACT_SITE 71 71 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 241
MTEGEGRIQL EPSWKARVGD WLLRPQMREL SAFLRQRKAA GARVFPPGPQ IFAAFDATPF
EQVKVVILGQ DPYHGEGQAH GLCFSVLPGV PVPPSLLNIY KEIQDDLGIA RPDHGYLMPW
ARQGVLLLNA VLTVEQGRAG AHQNKGWEGF TDHVVETLNR EREGLVFLLW GSYAQSKGKV
IDQTRHRVLK APHPSPLSAH RGFLGCQHFS KTNDHLRRRG LSPIDWSLPP RSALDLTSAG
A