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Description:
BTG2 protein (NGF-inducible anti-proliferative protein PC3).
Molecular weight: 17416
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
07-FEB-2006, entry version 38.
Phylogenetic order:
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Catarrhini Hominidae Homo.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein BTG2_HUMAN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U72649 | AAB37580.1 | - |
| EMBL | Y09943 | CAA71074.1 | - |
| EMBL | AF361937 | AAL05626.1 | - |
| EMBL | AL513326 | CAH70451.1 | - |
| Ensembl | ENSG00000159388 | Homo sapiens.1 | |
| HGNC | HGNC:1131 | BTG2.1 | |
| MIM | 601597 | gene. | |
| GO | GO:0006281 | P:DNA repair | TAS. |
| GO | GO:0008285 | P:negative regulation of cell proliferation | TAS. |
| InterPro | IPR002087 | Anti_prolifrtn. | |
| Pfam | PF07742 | BTG | 1. |
| PRINTS | PR00310 | ANTIPRLFBTG1. | |
| SMART | SM00099 | btg1 | 1. |
| PROSITE | PS00960 | BTG_1 | 1. |
| PROSITE | PS01203 | BTG_2 | 1. |
Keywords:
Transcription; Transcription regulation.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX MEDLINE=97099464; PubMed=8944033;
RA Rouault J.-P., Falette N., Guehenneux F., Guillot C., Rimokh R.,
RA Wang Q., Berthet C., Moyret-Lalle C., Savatier P., Pain B., Shaw P.,
RA Berger R., Samarut J., Magaud J.-P., Ozturk M., Samarut C.,
RA Puisieux A.;
RT "Identification of BTG2, an antiproliferative p53-dependent component
RT of the DNA damage cellular response pathway.";
RL Nat. Genet. 14:482-486(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetal liver;
RX PubMed=11267995; DOI=10.1002/jcp.1062;
RA Tirone F.;
RT "The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family:
RT regulator in control of cell growth, differentiation, and DNA
RT repair?";
RL J. Cell. Physiol. 187:155-165(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=21674004; PubMed=11814693; DOI=10.1016/S0378-1119(01)00825-3;
RA Duriez C., Falette N., Audoynaud C., Moyret-Lalle C., Bensaad K.,
RA Courtois S., Wang Q., Soussi T., Puisieux A.;
RT "The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional
RT regulation and evaluation as a candidate tumor suppressor gene.";
RL Gene 282:207-214(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND INTERACTION WITH THE CCR4-NOT COMPLEX.
RX PubMed=12771185; DOI=10.1242/jcs.00480;
RA Morel A.-P., Sentis S., Bianchin C., Le Romancer M., Jonard L.,
RA Rostan M.-C., Rimokh R., Corbo L.;
RT "BTG2 antiproliferative protein interacts with the human CCR4 complex
RT existing in vivo in three cell-cycle-regulated forms.";
RL J. Cell Sci. 116:2929-2936(2003).
Feature:
CHAIN 1 158 BTG2 protein.
/FTId=PRO_0000143804.
Comments:
-!- FUNCTION: Anti-proliferative protein. Modulates transcription
regulation mediated by ESR1.
-!- SUBUNIT: Interacts with PRKCABP (By similarity). Binds the CCR4-
NOT complex.
-!- SIMILARITY: Belongs to the BTG family.
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Sequence length: 158
MSHGKGTDML PEIAAAVGFL SSLLRTRGCV SEQRLKVFSG ALQEALTEHY KHHWFPEKPS
KGSGYRCIRI NHKMDPIISR VASQIGLSQP QLHQLLPSEL TLWVDPYEVS YRIGEDGSIC
VLYEEAPLAA SCGLLTCKNQ VLLGRSSPSK NYVMAVSS