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Description:
DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1)(UV-damaged DNA-binding factor) (DDB p127 subunit) (DDBa) (UV-damagedDNA-binding protein 1) (UV-DDB 1) (Xeroderma pigmentosum group E-complementing protein) (XPCe) (XPE-binding factor) (XPE-BF) (X-associated protein 1) (XAP-1).
Molecular weight: 1269
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
07-MAR-2006, entry version 40.
Phylogenetic order:
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Catarrhini Hominidae Homo.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DDB1_HUMAN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U18299 | AAC50349.1 | - |
| EMBL | L40326 | AAA62838.1 | - |
| EMBL | U32986 | AAA88883.1 | - |
| EMBL | AJ002955 | CAA05770.1 | - |
| EMBL | AY960579 | AAX44048.1 | - |
| EMBL | BC011686 | AAH11686.1 | - |
| EMBL | BC050530 | AAH50530.1 | - |
| EMBL | BC051764 | AAH51764.1 | - |
| PIR | I38908 | I38908. | |
| IntAct | Q16531 | -.1 | |
| Ensembl | ENSG00000167986 | Homo sapiens.1 | |
| H-InvDB | HIX0009685 | -.1 | |
| HGNC | HGNC:2717 | DDB1.1 | |
| MIM | 600045 | gene. | |
| Reactome | Q16531 | -.1 | |
| GO | GO:0003684 | F:damaged DNA binding | TAS. |
| GO | GO:0006289 | P:nucleotide-excision repair | TAS. |
| InterPro | IPR004871 | CPSF_A_C. | |
| Pfam | PF03178 | CPSF_A | 1. |
Keywords:
DNA damage; DNA repair; DNA-binding; Nuclear protein; Polymorphism; Ubl conjugation pathway.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Epidermis, and Fetal lung;
RX MEDLINE=96079092; PubMed=8530102;
RA Dualan R., Brody T., Keeney S., Nichols A.F., Admon A., Linn S.;
RT "Chromosomal localization and cDNA cloning of the genes (DDB1 and
RT DDB2) for the p127 and p48 subunits of a human damage-specific DNA
RT binding protein.";
RL Genomics 29:62-69(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Peripheral blood;
RX MEDLINE=95115068; PubMed=7815490;
RA Lee T.H., Elledge S.J., Butel J.S.;
RT "Hepatitis B virus X protein interacts with a probable cellular DNA
RT repair protein.";
RL J. Virol. 69:1107-1114(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=96140804; PubMed=8538642; DOI=10.1016/0921-8777(95)00040-2;
RA Hwang B.J., Liao J.C., Chu G.;
RT "Isolation of a cDNA encoding a UV-damaged DNA binding factor
RT defective in xeroderma pigmentosum group E cells.";
RL Mutat. Res. 362:105-117(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta, and Skin;
RA Huang S.L., Lin-Chao S., Chao C.K.;
RT "Molecular cloning and characterization of human XPE protein: a
RT component of UV-damaged DNA recognition activity.";
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PHE-427.
RA Livingston R.J., Rieder M.J., Rajkumar N., Downing T.K., Olson A.N.,
RA Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J.,
RA Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A.;
RT "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department
RT of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta, and Skin;
RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [7]
RP IDENTIFICATION IN THE DCX DET1-COP1 COMPLEX WITH RBX1; CUL4A; COP1 AND
RP DET1.
RX PubMed=14739464; DOI=10.1126/science.1093549;
RA Wertz I.E., O'Rourke K.M., Zhang Z., Dornan D., Arnott D.,
RA Deshaies R.J., Dixit V.M.;
RT "Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin
RT ligase.";
RL Science 303:1371-1374(2004).
Feature:
CHAIN 1 1140 DNA damage-binding protein 1.
/FTId=PRO_0000079840.
VARIANT 427 427 L -> F.
/FTId=VAR_023074.
CONFLICT 422 422 D -> Y (in Ref. 3).
CONFLICT 533 533 E -> G (in Ref. 4).
CONFLICT 869 869 A -> D (in Ref. 4).
CONFLICT 898 899 EL -> DV (in Ref. 3 and 4).
Comments:
-!- FUNCTION: Involved in the repair of UV-damaged DNA. Binds to
pyrimidine dimers.
-!- SUBUNIT: Heterodimer of DDB1 and DDB2. Component of the DCX DET1-
COP1 ubiquitin ligase complex at least composed of RBX1, DET1,
DDB1, CUL4A and COP1. Interacts with HBV X protein.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- SIMILARITY: Belongs to the DDB1 family.
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Sequence length: 1140
MSYNYVVTAQ KPTAVNGCVT GHFTSAEDLN LLIAKNTRLE IYVVTAEGLR PVKEVGMYGK
IAVMELFRPK GESKDLLFIL TAKYNACILE YKQSGESIDI ITRAHGNVQD RIGRPSETGI
IGIIDPECRM IGLRLYDGLF KVIPLDRDNK ELKAFNIRLE ELHVIDVKFL YGCQAPTICF
VYQDPQGRHV KTYEVSLREK EFNKGPWKQE NVEAEASMVI AVPEPFGGAI IIGQESITYH
NGDKYLAIAP PIIKQSTIVC HNRVDPNGSR YLLGDMEGRL FMLLLEKEEQ MDGTVTLKDL
RVELLGETSI AECLTYLDNG VVFVGSRLGD SQLVKLNVDS NEQGSYVVAM ETFTNLGPIV
DMCVVDLERQ GQGQLVTCSG AFKEGSLRII RNGIGIHEHA SIDLPGIKGL WPLRSDPNRE
TDDTLVLSFV GQTRVLMLNG EEVEETELMG FVDDQQTFFC GNVAHQQLIQ ITSASVRLVS
QEPKALVSEW KEPQAKNISV ASCNSSQVVV AVGRALYYLQ IHPQELRQIS HTEMEHEVAC
LDITPLGDSN GLSPLCAIGL WTDISARILK LPSFELLHKE MLGGEIIPRS ILMTTFESSH
YLLCALGDGA LFYFGLNIET GLLSDRKKVT LGTQPTVLRT FRSLSTTNVF ACSDRPTVIY
SSNHKLVFSN VNLKEVNYMC PLNSDGYPDS LALANNSTLT IGTIDEIQKL HIRTVPLYES
PRKICYQEVS QCFGVLSSRI EVQDTSGGTT ALRPSASTQA LSSSVSSSKL FSSSTAPHET
SFGEEVEVHN LLIIDQHTFE VLHAHQFLQN EYALSLVSCK LGKDPNTYFI VGTAMVYPEE
AEPKQGRIVV FQYSDGKLQT VAEKEVKGAV YSMVEFNGKL LASINSTVRL YEWTTEKELR
TECNHYNNIM ALYLKTKGDF ILVGDLMRSV LLLAYKPMEG NFEEIARDFN PNWMSAVEIL
DDDNFLGAEN AFNLFVCQKD SAATTDEERQ HLQEVGLFHL GEFVNVFCHG SLVMQNLGET
STPTQGSVLF GTVNGMIGLV TSLSESWYNL LLDMQNRLNK VIKSVGKIEH SFWRSFHTER
KTEPATGFID GDLIESFLDI SRPKMQEVVA NLQYDDGSGM KREATADDLI KVVEELTRIH