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Description:
DNA polymerase theta (EC 2.7.7.7) (DNA polymerase eta).
Molecular weight: 1975
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
07-FEB-2006, entry version 34.
Phylogenetic order:
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Catarrhini Hominidae Homo.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DPOQ_HUMAN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF052573 | AAC33565.1 | - |
| EMBL | AF043628 | AAD05272.1 | - |
| HSSP | P00582 | 1KFS | |
| Ensembl | ENSG00000051341 | Homo sapiens.1 | |
| HGNC | HGNC:9186 | POLQ.1 | |
| MIM | 604419 | gene. | |
| GO | GO:0005654 | C:nucleoplasm | TAS. |
| GO | GO:0003684 | F:damaged DNA binding | TAS. |
| GO | GO:0003887 | F:DNA-directed DNA polymerase activity | TAS. |
| GO | GO:0006281 | P:DNA repair | TAS. |
| InterPro | IPR001098 | DNA_pol. | |
| InterPro | IPR002298 | DNA_polI. | |
| Pfam | PF00476 | DNA_pol_A | 1. |
| PRINTS | PR00868 | DNAPOLI. | |
| SMART | SM00482 | POLAc | 1. |
| PROSITE | PS00447 | DNA_POLYMERASE_A | 1. |
Keywords:
ATP-binding; DNA damage; DNA repair; DNA-directed DNA polymerase; Nucleotide-binding; Nucleotidyltransferase; Transferase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spleen;
RX MEDLINE=99326527; PubMed=10395804; DOI=10.1006/geno.1999.5843;
RA Sharief F.S., Vojta P.J., Ropp P.A., Copeland W.C.;
RT "Cloning and chromosomal mapping of the human DNA polymerase theta
RT (POLQ), the eighth human DNA polymerase.";
RL Genomics 59:90-96(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 607-1762.
RA Harris P.V., Kaelin C.B., Burtis K.C.;
RT "Catalytic activity of Pol eta, a new human DNA polymerase related to
RT the bacterial DNA polymerase I family and Drosophila Mus308.";
RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 1762 DNA polymerase theta.
/FTId=PRO_0000101279.
NP_BIND 175 182 ATP (Potential).
CONFLICT 1185 1185 L -> F (in Ref. 2).
CONFLICT 1685 1685 R -> Q (in Ref. 2).
CONFLICT 1719 1719 V -> A (in Ref. 2).
CONFLICT 1756 1762 ELKDFDV -> RAKGL (in Ref. 2).
Comments:
-!- FUNCTION: Could be involved in the repair of interstrand
crosslinks.
-!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
diphosphate + DNA(n+1).
-!- SIMILARITY: Belongs to the DNA polymerase type-A family.
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Sequence length: 1762
MNSFLSFPIS LCSARKAVDE EEEAVEERRN MRTIWVTGRK GLTEREAAAL IVEEARMILQ
QDLVEMGVQW NPCALLHSST CSLTHSESEV KEHTFISQTK SSYKKLTSKN KSNTIFSDSY
IKHSPNIVQD LNKSREHTSS FNCNFQNGNQ EHQTCSIFRA RKRASLDINK EKPGASQNEG
KTSDKKVVQT FSQKTKKAPL NFNSEKMSRS FRSWKRRKHL KRSRDSSPLK DSGACRIHLQ
GQTLSNPSLC EDPFTLDEKK TEFRNSGPFA KNVSLSGKEK DNKTSFPLQI KQNCSWNITL
TNDNFVEHIV TGSQSKNVTC QATSVVSEKG RGVAVEAEKI NEVLIQNGSK NQNVYMKHHD
IHPINQYLRK QSHEQTSTIT KQKNIIERQM PCEAVSSYIN RDSNVTINCE RIKLNTEENK
PSHFQALGDD ISRTVIPSEV LPSAGAFSKS EGQHENFLNI SRLQEKTGTY TTNKTKNNHV
SDLGLVLCDF EDSFYLDTQS EKIIQQMATE NAKLGAKDTN LAAGIMQKSL VQQNSMNSFQ
KECHIPFPAE QHPLGATKID HLDLKTVGTM KQSSDSHGVD ILTPESPIFH SPILLEENGL
FLKKNEVSVT DSQLNSFLQG YQTQETVKPV ILLIPQKRTP TGVEGECLPV PETSLNMSDS
LLFDSFSDDY LVKEQLPDMQ MKEPLPSEVT SNHFSDSLCL QEDLIKKSNV NENQDTHQQL
TCSNDESIIF SEMDSVQMVE ALDNVDIFPV QEKNHTVVSP RALELSDPVL DEHHQGDQDG
GDQDERAEKS KLTGTRQNHS FIWSGASFDL SPGLQRILDK VSSPLENEKL KSMTINFSSL
NRKNTELNEE QEVISNLETK QVQGISFSSN NEVKSKIEML ENNANHDETS SLLPRKESNI
VDDNGLIPPT PIPTSASKLT FPGILETPVN PWKTNNVLQP GESYLFGSPS DIKNHDLSPG
SRNGFKDNSP ISDTSFSLQL SQDGLQLTPA SSSSESLSII DVASDQNLFQ TFIKEWRCKK
RFSISLACEK IRSLTSSKTA TIGSRFKQAS SPQEIPIRDD GFPIKGCDDT LVVGLAVCWG
GRDAYYFSLQ KEQKHSEISA SLVPPSLDPS LTLKDRMWYL QSCLRKESDK ECSVVIYDFI
QSYKILLLSC GISLEQSYED PKVACWLLDP DSQEPTLHSI VTSFLPHELP LLEGMETSQG
IQSLGLNAGS EHSGRYRASV ESILIFNSMN QLNSLLQKEN LQDVFRKVEM PSQYCLALLE
LNGIGFSTAE CESQKHIMQA KLDAIETQAY QLAGHSFSFT SSDDIAEVLF LELKLPPNRE
MKNQGSKKTL GSTRRGIDNG RKLRLGRQFS TSKDVLNKLK ALHPLPGLIL EWRRITNAIT
KVVFPLQREK CLNPFLGMER IYPVSQSHTA TGRITFTEPN IQNVPRDFEI KMPTLVGESP
PSQAVGKGLL PMGRGKYKKG FSVNPRCQAQ MEERAADRGM PFSISMRHAF VPFPGGSILA
ADYSQLELRI LAHLSHDRRL IQVLNTGADV FRSIAAEWKM IEPESVGDDL RQQAKQICYG
IIYGMGAKSL GEQMGIKEND AACYIDSFKS RYTGINQFMT ETVKNCKRDG FVQTILGRRR
YLPGIKDNNP YRKAHAERQA INTIVQGSAA DIVKIATVNI QKQLETFHST FKSHGHREGM
LQSDRTGLSR KRKLQGMFCP IRGGFFILQL HDELLYEVVE EDVVQVAQIV KNEMESAVKL
SVKLKVKVKI GASWGELKDF DV