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Description:
High mobility group protein 1 (HMG-1) (High mobility group proteinB1).
Molecular weight: 24763
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair, DNA ligation( GO:0006288 )
Important dates:
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-AUG-1990, sequence version 2.
07-FEB-2006, entry version 61.
Phylogenetic order:
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Catarrhini Hominidae Homo.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein HMG1_HUMAN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | X12597 | CAA31110.1 | - |
| EMBL | U51677 | AAB08987.1 | - |
| EMBL | AY377859 | AAQ91389.1 | - |
| EMBL | CR749614 | CAH18408.1 | - |
| EMBL | CR456863 | CAG33144.1 | - |
| EMBL | BT006940 | AAP35586.1 | - |
| EMBL | BT020159 | AAV38961.1 | - |
| EMBL | BC003378 | AAH03378.1 | - |
| EMBL | BC030981 | AAH30981.1 | - |
| EMBL | BC066889 | AAH66889.1 | - |
| EMBL | BC067732 | AAH67732.1 | - |
| PIR | S02826 | S02826. | |
| HSSP | P07156 | 1NHN | |
| SMR | P09429 | 1-83, 92-170.1 | |
| IntAct | P09429 | -.1 | |
| Ensembl | ENSG00000189403 | Homo sapiens.1 | |
| H-InvDB | HIX0011209 | -.1 | |
| HGNC | HGNC:4983 | HMGB1.1 | |
| MIM | 163905 | gene. | |
| LinkHub | P09429 | -.1 | |
| GO | GO:0000793 | C:condensed chromosome | IDA. |
| GO | GO:0008301 | F:DNA bending activity | TAS. |
| GO | GO:0008134 | F:transcription factor binding | TAS. |
| GO | GO:0006288 | P:base-excision repair, DNA ligation | IDA. |
| GO | GO:0006310 | P:DNA recombination | TAS. |
| GO | GO:0006281 | P:DNA repair | TAS. |
| GO | GO:0006268 | P:DNA unwinding | NAS. |
| GO | GO:0006325 | P:establishment and/or maintenance of chromat... | TAS. |
| GO | GO:0017055 | P:negative regulation of transcriptional prei... | IDA. |
| GO | GO:0006357 | P:regulation of transcription from RNA polyme... | IDA. |
| InterPro | IPR000135 | Highmoblty_12. | |
| InterPro | IPR000910 | HMG_12_box. | |
| Pfam | PF00505 | HMG_box | 2. |
| PRINTS | PR00886 | HIGHMOBLTY12. | |
| SMART | SM00398 | HMG | 2. |
| PROSITE | PS00353 | HMG_BOX_1 | 1. |
| PROSITE | PS50118 | HMG_BOX_2 | 2. |
Keywords:
Chromosomal protein; Direct protein sequencing; DNA-binding; Nuclear protein; Repeat.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX MEDLINE=89160247; PubMed=2922262;
RA Wen L., Huang J.K., Johnson B.H., Reeck G.R.;
RT "A human placental cDNA clone that encodes nonhistone chromosomal
RT protein HMG-1.";
RL Nucleic Acids Res. 17:1197-1214(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=96299787; PubMed=8661151; DOI=10.1006/geno.1996.0369;
RA Ferrari S., Finelli P., Rocchi M., Bianchi M.E.;
RT "The active gene that encodes human high mobility group 1 protein
RT (HMG1) contains introns and maps to chromosome 13.";
RL Genomics 35:367-371(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA He F.T., Yang Z.H., Ji Q., Li R., Peng J., Jiang Y., Zhong X.;
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Cervix, and Testis;
RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [8]
RP PROTEIN SEQUENCE OF 57-64 AND 112-126.
RC TISSUE=Mammary carcinoma;
RX MEDLINE=97295304; PubMed=9150946;
RA Rasmussen R.K., Ji H., Eddes J.S., Moritz R.L., Reid G.E.,
RA Simpson R.J., Dorow D.S.;
RT "Two-dimensional electrophoretic analysis of human breast carcinoma
RT proteins: mapping of proteins that bind to the SH3 domain of mixed
RT lineage kinase MLK2.";
RL Electrophoresis 18:588-598(1997).
Feature:
INIT_MET 0 0
CHAIN 1 214 High mobility group protein 1.
/FTId=PRO_0000048526.
DNA_BIND 8 78 HMG box 1.
DNA_BIND 94 162 HMG box 2.
COMPBIAS 185 214 Asp/Glu-rich (acidic).
CONFLICT 214 214 E -> D (in Ref. 5).
Comments:
-!- FUNCTION: Binds preferentially single-stranded DNA and unwinds
double stranded DNA.
-!- INTERACTION:
P04637:TP53; NbExp=1; IntAct=EBI-389432, EBI-366083;
O15350:TP73; NbExp=1; IntAct=EBI-389432, EBI-389606;
-!- SUBCELLULAR LOCATION: Nucleus.
-!- SIMILARITY: Belongs to the HMG1/HMG2 protein family.
-!- SIMILARITY: Contains 2 HMG box DNA-binding domains.
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Sequence length: 214
GKGDPKKPRG KMSSYAFFVQ TCREEHKKKH PDASVNFSEF SKKCSERWKT MSAKEKGKFE
DMAKADKARY EREMKTYIPP KGETKKKFKD PNAPKRPPSA FFLFCSEYRP KIKGEHPGLS
IGDVAKKLGE MWNNTAADDK QPYEKKAAKL KEKYEKDIAA YRAKGKPDAA KKGVVKAEKS
KKKKEEEEDE EDEEDEEEEE DEEDEDEEED DDDE