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Description:
High mobility group protein 2 (HMG-2).
Molecular weight: 23903
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair, DNA ligation( GO:0006288 )
Important dates:
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
01-AUG-1992, sequence version 1.
07-FEB-2006, entry version 54.
Phylogenetic order:
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Catarrhini Hominidae Homo.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein HMG2_HUMAN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | M83665 | AAA58659.1 | - |
| EMBL | X62534 | CAA44395.1 | - |
| EMBL | BC001063 | AAH01063.1 | - |
| EMBL | Z17240 | CAA78938.1 | - |
| PIR | A42425 | NSHUH2. | |
| PIR | S30221 | S30221. | |
| HSSP | P07155 | 1CKT | |
| SMR | P26583 | 1-76, 88-164.1 | |
| Ensembl | ENSG00000164104 | Homo sapiens.1 | |
| HGNC | HGNC:5000 | HMGB2.1 | |
| MIM | 163906 | gene. | |
| LinkHub | P26583 | -.1 | |
| GO | GO:0000793 | C:condensed chromosome | IDA. |
| GO | GO:0000228 | C:nuclear chromosome | TAS. |
| GO | GO:0048471 | C:perinuclear region | IDA. |
| GO | GO:0008301 | F:DNA bending activity | IDA. |
| GO | GO:0003690 | F:double-stranded DNA binding | TAS. |
| GO | GO:0003697 | F:single-stranded DNA binding | TAS. |
| GO | GO:0003700 | F:transcription factor activity | TAS. |
| GO | GO:0006288 | P:base-excision repair, DNA ligation | IDA. |
| GO | GO:0006281 | P:DNA repair | TAS. |
| GO | GO:0006260 | P:DNA replication | TAS. |
| GO | GO:0006268 | P:DNA unwinding | TAS. |
| GO | GO:0006325 | P:establishment and/or maintenance of chromat... | NAS. |
| GO | GO:0006334 | P:nucleosome assembly | NAS. |
| GO | GO:0048015 | P:phosphoinositide-mediated signaling | NAS. |
| GO | GO:0006357 | P:regulation of transcription from RNA polyme... | IDA. |
| InterPro | IPR000135 | Highmoblty_12. | |
| InterPro | IPR000910 | HMG_12_box. | |
| Pfam | PF00505 | HMG_box | 2. |
| PRINTS | PR00886 | HIGHMOBLTY12. | |
| SMART | SM00398 | HMG | 2. |
| PROSITE | PS00353 | HMG_BOX_1 | 1. |
| PROSITE | PS50118 | HMG_BOX_2 | 2. |
Keywords:
Chromosomal protein; DNA-binding; Nuclear protein; Phosphorylation; Repeat.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=92093633; PubMed=1754403;
RA Majumdar A., Brown D., Kerby S., Rudzinski I., Polte T., Randawa Z.,
RA Seidman M.M.;
RT "Sequence of human HMG2 cDNA.";
RL Nucleic Acids Res. 19:6643-6643(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=92202209; PubMed=1551873;
RA Shirakawa H., Yoshida M.;
RT "Structure of a gene coding for human HMG2 protein.";
RL J. Biol. Chem. 267:6641-6645(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 23-208.
RX MEDLINE=93117123; PubMed=1475204;
RA Alexandre S., Li W.W., Lee A.S.;
RT "A human HMG2 cDNA with a novel 3'-untranslated region.";
RL Nucleic Acids Res. 20:6413-6413(1992).
RN [5]
RP INTERACTION WITH SET.
RX PubMed=11909973; DOI=10.1128/MCB.22.8.2810-2820.2002;
RA Fan Z., Beresford P.J., Zhang D., Lieberman J.;
RT "HMG2 interacts with the nucleosome assembly protein SET and is a
RT target of the cytotoxic T-lymphocyte protease granzyme A.";
RL Mol. Cell. Biol. 22:2810-2820(2002).
Feature:
INIT_MET 0 0 By similarity.
CHAIN 1 208 High mobility group protein 2.
/FTId=PRO_0000048534.
DNA_BIND 8 78 HMG box 1.
DNA_BIND 94 162 HMG box 2.
COMPBIAS 185 208 Asp/Glu-rich (acidic).
MOD_RES 34 34 Phosphoserine (By similarity).
CONFLICT 162 162 R -> G (in Ref. 4).
Comments:
-!- FUNCTION: Binds preferentially single-stranded DNA and unwinds
double stranded DNA.
-!- SUBUNIT: Component of the SET complex, which also contains SET,
ANP32A, APEX1 and NME1. Directly interacts with SET.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- SIMILARITY: Belongs to the HMG1/HMG2 protein family.
-!- SIMILARITY: Contains 2 HMG box DNA-binding domains.
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Sequence length: 208
GKGDPNKPRG KMSSYAFFVQ TCREEHKKKH PDSSVNFAEF SKKCSERWKT MSAKEKSKFE
DMAKSDKARY DREMKNYVPP KGDKKGKKKD PNAPKRPPSA FFLFCSEHRP KIKSEHPGLS
IGDTAKKLGE MWSEQSAKDK QPYEQKAAKL KEKYEKDIAA YRAKGKSEAG KKGPGRPTGS
KKKNEPEDEE EEEEEEDEDE EEEDEDEE