|
|
|
|
|
|
Description:
Casein kinase I isoform delta (EC 2.7.1.-) (CKI-delta) (CKId).
Molecular weight: 47330
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
27-JAN-2003, sequence version 2.
07-MAR-2006, entry version 52.
Phylogenetic order:
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Catarrhini Hominidae Homo.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein KC1D_HUMAN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U29171 | AAC50807.1 | - |
| EMBL | U31285 | AAC50808.1 | - |
| EMBL | AB091044 | BAC10903.1 | - |
| EMBL | BC003558 | AAH03558.1 | - |
| EMBL | BC015775 | AAH15775.1 | - |
| PIR | G01876 | G01876. | |
| HSSP | Q06486 | 1CKJ | |
| SMR | P48730 | 1-296.1 | |
| Ensembl | ENSG00000141551 | Homo sapiens.1 | |
| HGNC | HGNC:2452 | CSNK1D.1 | |
| MIM | 600864 | gene. | |
| GO | GO:0004681 | F:casein kinase I activity | TAS. |
| GO | GO:0006281 | P:DNA repair | TAS. |
| GO | GO:0006468 | P:protein amino acid phosphorylation | TAS. |
| GO | GO:0007165 | P:signal transduction | TAS. |
| InterPro | IPR000719 | Prot_kinase. | |
| InterPro | IPR008271 | Ser_thr_pkin_AS. | |
| InterPro | IPR002290 | Ser_thr_pkinase. | |
| InterPro | IPR001245 | Tyr_pkinase. | |
| Pfam | PF00069 | Pkinase | 1. |
| ProDom | PD000001 | Prot_kinase | 1. |
| PROSITE | PS00107 | PROTEIN_KINASE_ATP | 1. |
| PROSITE | PS50011 | PROTEIN_KINASE_DOM | 1. |
| PROSITE | PS00108 | PROTEIN_KINASE_ST | 1. |
Keywords:
Alternative splicing; ATP-binding; Kinase; Nucleotide-binding; Phosphorylation; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORM 1).
RC TISSUE=Brain;
RX MEDLINE=96230338; PubMed=8786104; DOI=10.1006/geno.1996.0091;
RA Kusuda J., Hidari N., Hidari M., Hashimoto K.;
RT "Sequence analysis of the cDNA for the human casein kinase I delta
RT (CSNK1D) gene and its chromosomal localization.";
RL Genomics 32:140-143(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE (ISOFORM 1).
RA Okamura A., Iwata N., Tamekane A., Nagata A., Shimoyama M., Gomyo H.,
RA Hamaguchi M., Chihara K., Ito M., Matsui T.;
RT "Involvement of casein kinase I epsilon in cytokine-induced
RT granulocytic differentiation.";
RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Placenta, and Spleen;
RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
Feature:
CHAIN 1 415 Casein kinase I isoform delta.
/FTId=PRO_0000192833.
DOMAIN 9 277 Protein kinase.
NP_BIND 15 23 ATP (By similarity).
ACT_SITE 128 128 Proton acceptor (By similarity).
BINDING 38 38 ATP (By similarity).
VARSPLIC 400 415 IPGRVASSGLQSVVHR -> NSIPFEHHGK (in
isoform 2).
/FTId=VSP_010253.
CONFLICT 330 330 A -> D (in Ref. 1).
Comments:
-!- FUNCTION: Casein kinases are operationally defined by their
preferential utilization of acidic proteins such as caseins as
substrates. It can phosphorylate a large number of proteins.
Participates in Wnt signaling.
-!- ENZYME REGULATION: Exhibits substrate-dependent heparin
activation.
-!- SUBUNIT: Monomer.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P48730-1; Sequence=Displayed;
Name=2;
IsoId=P48730-2; Sequence=VSP_010253;
-!- PTM: Autophosphorylated (By similarity).
-!- SIMILARITY: Belongs to the Ser/Thr protein kinase family. Casein
kinase I subfamily.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 415
MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH IESKIYKMMQ
GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH
SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA
SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL
CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA
ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS HTANTSPRPV
SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQI PGRVASSGLQ SVVHR