Protein data for MCA3_HUMAN:

Description:
Eukaryotic translation elongation factor 1 epsilon-1 (Multisynthetasecomplex auxiliary component p18) (Elongation factor p18).

Molecular weight: 19811

View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )

Important dates:
18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
07-MAR-2006, entry version 39.

Phylogenetic order:
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Catarrhini Hominidae Homo.

To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html

Links to references in other databases for protein MCA3_HUMAN:

Database Pointer Add. info#1 Add. info#2
EMBL AB011079 BAA24926.1 -
EMBL AF054186 AAC39916.1 -
EMBL BT007306 AAP35970.1 -
EMBL AL355499 CAH72539.1 -
EMBL AL023694 CAH72539.1 JOINED
EMBL AL451187 CAH72539.1 JOINED
EMBL AL023694 CAI21644.1 -
EMBL AL355499 CAI21644.1 JOINED
EMBL AL451187 CAI21644.1 JOINED
EMBL AL451187 CAI14747.1 -
EMBL AL023694 CAI14747.1 JOINED
EMBL AL355499 CAI14747.1 JOINED
EMBL BC005291 AAH05291.1 -
Ensembl ENSG00000124802 Homo sapiens.1
H-InvDB HIX0005569 -.1
HGNC HGNC:3212 EEF1E1.1
MIM 609206 gene.
LinkHub O43324 -.1
InterPro IPR004046 GST_C.
Pfam PF00043 GST_C 1.

General information about the databases mentioned above

Keywords:
Nuclear protein; Protein biosynthesis.

References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis;
RA Motegi H., Noda T., Shiba K.;
RT "Cloning of cDNA for human p18 from human testis.";
RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX MEDLINE=98318631; PubMed=9653160; DOI=10.1073/pnas.95.14.8175;
RA Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H.,
RA He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H.,
RA Wang Y.-X., Chen S.-J., Chen Z.;
RT "Identification of genes expressed in human CD34(+) hematopoietic
RT stem/progenitor cells by expressed sequence tags and efficient full-
RT length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=22935763; PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Urinary bladder;
RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [6]
RP INTERACTION WITH ATM, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=15680327; DOI=10.1016/j.cell.2004.11.054;
RA Park B.-J., Kang J.W., Lee S.W., Choi S.-J., Shin Y.K., Ahn Y.H.,
RA Choi Y.H., Choi D., Lee K.S., Kim S.;
RT "The haploinsufficient tumor suppressor p18 upregulates p53 via
RT interactions with ATM/ATR.";
RL Cell 120:209-221(2005).

Feature:
CHAIN 1 174 Eukaryotic translation elongation factor
1 epsilon-1.
/FTId=PRO_0000221132.
DOMAIN 87 153 GST-like.

Comments:
-!- FUNCTION: Positive modulator of ATM response to DNA damage.
-!- SUBUNIT: Component of the multisynthetase complex which is
comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the
monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl,
arginyl, and aspartyl-tRNA synthetases as well as three auxiliary
proteins, p18, p48 and p43. Interacts with ATM and ATR. The
interaction with ATM, which takes place independently of TP53, is
induced by DNA damage that may occur during genotoxic stress or
cell growth. The interaction with ATR is enhanced by UV
irradiation.
-!- SUBCELLULAR LOCATION: Cytoplasmic under growth arrest conditions.
Translocated into the nucleus when growth resumes (S phase), and
following DNA damage.
-!- TISSUE SPECIFICITY: Down-regulated in various cancer tissues.
-!- INDUCTION: By DNA damaging agents, such as UV, adriamycin,
actinomycin D and cisplatin.
-!- SIMILARITY: Contains 1 GST-like domain.
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Sequence length: 174

     MAAAAELSLL EKSLGLSKGN KYSAQGERQI PVLQTNNGPS LTGLTTIAAH LVKQANKEYL
     LGSTAEEKAI VQQWLEYRVT QVDGHSSKND IHTLLKDLNS YLEDKVYLTG YNFTLADILL
     YYGLHRFIVD LTVQEKEKYL NVSRWFCHIQ HYPGIRQHLS SVVFIKNRLY TNSH

Back

Database	Pointer	Add. info#1	Add. info#2
EMBL	AB011079	BAA24926.1	-
EMBL	AF054186	AAC39916.1	-
EMBL	BT007306	AAP35970.1	-
EMBL	AL355499	CAH72539.1	-
EMBL	AL023694	CAH72539.1	JOINED
EMBL	AL451187	CAH72539.1	JOINED
EMBL	AL023694	CAI21644.1	-
EMBL	AL355499	CAI21644.1	JOINED
EMBL	AL451187	CAI21644.1	JOINED
EMBL	AL451187	CAI14747.1	-
EMBL	AL023694	CAI14747.1	JOINED
EMBL	AL355499	CAI14747.1	JOINED
EMBL	BC005291	AAH05291.1	-
Ensembl	ENSG00000124802	Homo sapiens.1
H-InvDB	HIX0005569	-.1
HGNC	HGNC:3212	EEF1E1.1
MIM	609206	gene.
LinkHub	O43324	-.1
InterPro	IPR004046	GST_C.
Pfam	PF00043	GST_C	1.