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Description:
Spermatid nuclear transition protein 1 (STP-1) (TP-1).
Molecular weight: 6293 M
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
single strand break repair( GO:0000012 )
Important dates:
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
07-FEB-2006, entry version 45.
Phylogenetic order:
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Catarrhini Hominidae Homo.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein STP1_HUMAN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | M59924 | AAA61202.1 | - |
| EMBL | X07948 | CAA30774.1 | - |
| EMBL | BC029516 | AAH29516.1 | - |
| PIR | A37106 | BGHU. | |
| Ensembl | ENSG00000118245 | Homo sapiens.1 | |
| H-InvDB | HIX0002816 | -.1 | |
| HGNC | HGNC:11951 | TNP1.1 | |
| MIM | 190231 | gene. | |
| GO | GO:0000786 | C:nucleosome | IDA. |
| GO | GO:0003677 | F:DNA binding | IMP. |
| GO | GO:0006338 | P:chromatin remodeling | IDA. |
| GO | GO:0006342 | P:chromatin silencing | IEP. |
| GO | GO:0035042 | P:fertilization, exchange of chromosomal prot... | TAS. |
| GO | GO:0006337 | P:nucleosome disassembly | IMP. |
| GO | GO:0019953 | P:sexual reproduction | IMP. |
| GO | GO:0000012 | P:single strand break repair | IDA. |
| GO | GO:0030317 | P:sperm motility | IMP. |
| GO | GO:0007290 | P:spermatid nuclear elongation | IMP. |
| InterPro | IPR001319 | TP1. | |
| PANTHER | PTHR17486 | TP.1 | 1. |
| Pfam | PF02079 | TP1 | 1. |
| ProDom | PD010292 | TP1 | 1. |
| PROSITE | PS00541 | TP1 | 1. |
Keywords:
Chromosomal protein; Developmental protein; Differentiation; DNA-binding; Nuclear protein; Nucleosome core; Spermatogenesis.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=88319961; PubMed=3412903;
RA Luerssen H., Hoyer-Fender S., Engel W.;
RT "The nucleotide sequence of human transition protein 1 cDNA.";
RL Nucleic Acids Res. 16:7723-7723(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=91065651; PubMed=2249851;
RA Luerssen H., Mattei M.-G., Schroeter M., Grzeschik K.H., Adham I.M.,
RA Engel W.;
RT "Nucleotide sequence of the gene for human transition protein 1 and
RT its chromosomal localization on chromosome 2.";
RL Genomics 8:324-330(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
Feature:
INIT_MET 0 0
CHAIN 1 54 Spermatid nuclear transition protein 1.
/FTId=PRO_0000191417.
Comments:
-!- FUNCTION: In the elongating spermatids of mammals, the conversion
of nucleosomal chromatin to the compact, nonnucleosomal form found
in the sperm nucleus is associated with the appearance of a small
set of basic chromosomal transition proteins.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Testis.
-!- SIMILARITY: Belongs to the nuclear transition protein 1 family.
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Sequence length: 54
STSRKLKSHG MRRSKSRSPH KGVKRGGSKR KYRKGNLKSR KRGDDANRNY RSHL