|
|
|
|
|
|
Description:
Uracil-DNA glycosylase 2 (EC 3.2.2.-) (UDG 2).
Molecular weight: 35352
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
01-AUG-1991, sequence version 1.
07-FEB-2006, entry version 43.
Phylogenetic order:
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Catarrhini Hominidae Homo.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG2_HUMAN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | X52486 | CAA36728.1 | - |
| PIR | S14266 | S14266. | |
| Ensembl | ENSG00000152669 | Homo sapiens.1 | |
| HGNC | HGNC:18576 | UNG2.1 | |
| MIM | 607752 | gene. | |
| Reactome | P22674 | -.1 | |
| LinkHub | P22674 | -.1 | |
| GO | GO:0005634 | C:nucleus | TAS. |
| GO | GO:0004844 | F:uracil DNA N-glycosylase activity | TAS. |
| GO | GO:0006284 | P:base-excision repair | TAS. |
| InterPro | IPR006670 | Cyclin. | |
| InterPro | IPR006671 | Cyclin_N. | |
| Pfam | PF00134 | Cyclin_N | 1. |
| SMART | SM00385 | CYCLIN | 1. |
Keywords:
DNA damage; DNA repair; Glycosidase; Hydrolase; Nuclear protein.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=T-cell;
RX MEDLINE=91159471; PubMed=2001396; DOI=10.1016/0167-4781(91)90055-Q;
RA Muller S.J., Caradonna S.;
RT "Isolation and characterization of a human cDNA encoding uracil-DNA
RT glycosylase.";
RL Biochim. Biophys. Acta 1088:197-207(1991).
RN [2]
RP SUBCELLULAR LOCATION.
RX MEDLINE=22694182; PubMed=12810074; DOI=10.1016/S0006-291X(03)01036-2;
RA Elder R.T., Zhu X., Priet S., Chen M., Yu M., Navarro J.-M., Sire J.,
RA Zhao Y.;
RT "A fission yeast homologue of the human uracil-DNA-glycosylase and
RT their roles in causing DNA damage after overexpression.";
RL Biochem. Biophys. Res. Commun. 306:693-700(2003).
Feature:
CHAIN 1 326 Uracil-DNA glycosylase 2.
/FTId=PRO_0000176175.
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- SIMILARITY: Belongs to the cyclin family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 326
MEPLPSFELL SPLREVTLYD ALCTAPGPNP GVPAQQARSV SSFHCVSLSE LFLPLSWEAP
RFFLALPSLP QLPLHPKPSG PASPPPSRQV TAESRCKLLS WLIPVHRQFG LSFESLCLTV
NTLDRFLTTT PVLQTASSCL GSPPCSSLAN RWRCTRRAWK QLLALCCGAF SRQQLCNLEC
IRAAQAALHP GCATISFFLT FQHLLSAARP PKLWKRKPWR RGVAELSLAD YAFTSYSPSL
LAICCLALAD RMLRLAARGL ATGRPPGGGA GGLYGQVAAA GGHKQYFLDS HAARSDLREV
QPAPELEIKQ ILRFLLVPGP AAGPLP