Description:
5'-3' exoribonuclease 2 (EC 3.1.11.-) (DHM1-like protein) (DHPprotein).
Molecular weight: 10858
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
23-APR-2003, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
07-FEB-2006, entry version 31.
Phylogenetic order:
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Catarrhini Hominidae Homo.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein XRN2_HUMAN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF064257 | AAD55138.1 | - |
| EMBL | AF152169 | AAQ13577.1 | - |
| EMBL | AL136841 | CAB66775.1 | - |
| EMBL | AL117332 | CAI19756.1 | - |
| EMBL | AL158013 | CAI19756.1 | JOINED |
| EMBL | AL158013 | CAH71495.1 | - |
| EMBL | AL117332 | CAH71495.1 | JOINED |
| EMBL | AK000084 | BAA90934.1 | ALT_INIT |
| EMBL | BC006417 | AAH06417.2.1 | - |
| IntAct | Q9H0D6 | -.1 | |
| SWISS-2DPAGE | Q9H0D6 | HUMAN. | |
| Ensembl | ENSG00000088930 | Homo sapiens.1 | |
| HGNC | HGNC:12836 | XRN2.1 | |
| MIM | 608851 | gene. | |
| GO | GO:0005634 | C:nucleus | ISS. |
| GO | GO:0004534 | F:5'-3' exoribonuclease activity | TAS. |
| GO | GO:0004518 | F:nuclease activity | TAS. |
| GO | GO:0005515 | F:protein binding | IPI. |
| GO | GO:0016049 | P:cell growth | ISS. |
| GO | GO:0006310 | P:DNA recombination | ISS. |
| GO | GO:0006281 | P:DNA repair | ISS. |
| GO | GO:0007017 | P:microtubule-based process | ISS. |
| GO | GO:0006401 | P:RNA catabolism | TAS. |
| GO | GO:0006396 | P:RNA processing | TAS. |
| GO | GO:0007283 | P:spermatogenesis | IEP. |
| InterPro | IPR004859 | Put_53exo. | |
| InterPro | IPR001878 | Znf_CCHC. | |
| Pfam | PF03159 | XRN_N | 1. |
| PROSITE | PS50158 | ZF_CCHC | FALSE_NEG. |
Keywords:
Exonuclease; Hydrolase; Metal-binding; mRNA processing; Nuclear protein; Nuclease; Phosphorylation; RNA-binding; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX MEDLINE=99339991; PubMed=10409438; DOI=10.1006/geno.1999.5866;
RA Zhang M., Yu L., Xin Y., Hu P., Fu Q., Yu C., Zhao S.Y.;
RT "Cloning and mapping of the XRN2 gene to human chromosome 20p11.1-
RT p11.2.";
RL Genomics 59:252-254(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX MEDLINE=21154917; PubMed=11230166; DOI=10.1101/gr.154701;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=21638749; PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 358-950.
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 371-950.
RC TISSUE=Colon;
RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX MEDLINE=22317277; PubMed=12429849; DOI=10.1091/mbc.E02-05-0271;
RA Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C.,
RA Greco A., Hochstrasser D.F., Diaz J.-J.;
RT "Functional proteomic analysis of human nucleolus.";
RL Mol. Biol. Cell 13:4100-4109(2002).
RN [7]
RP PHOSPHORYLATION SITES SER-448; SER-499 AND SER-501.
RX PubMed=15302935; DOI=10.1073/pnas.0404720101;
RA Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,
RA Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
RT "Large-scale characterization of HeLa cell nuclear phosphoproteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Feature:
CHAIN 1 950 5'-3' exoribonuclease 2.
/FTId=PRO_0000071396.
ZN_FING 262 278 CCHC-type.
MOD_RES 448 448 Phosphoserine.
MOD_RES 499 499 Phosphoserine.
MOD_RES 501 501 Phosphoserine.
CONFLICT 14 14 Y -> C (in Ref. 1; AAQ13577).
CONFLICT 109 109 A -> V (in Ref. 1).
CONFLICT 122 124 SKE -> IKR (in Ref. 1; AAD55138).
CONFLICT 240 245 GLATHE -> AFPHMN (in Ref. 1; AAQ13577).
CONFLICT 259 259 K -> R (in Ref. 1).
CONFLICT 280 280 P -> S (in Ref. 1).
CONFLICT 313 313 L -> V (in Ref. 1; AAQ13577).
CONFLICT 463 463 E -> D (in Ref. 1; AAD55138).
CONFLICT 582 582 P -> S (in Ref. 1; AAQ13577).
CONFLICT 584 584 D -> E (in Ref. 1).
CONFLICT 737 737 S -> A (in Ref. 1; AAD55138).
CONFLICT 787 787 E -> G (in Ref. 1; AAD55138).
Comments:
-!- FUNCTION: Possesses 5'->3' exoribonuclease activity and may be
involved in homologous recombination and RNA metabolism, such as
RNA synthesis and RNA trafficking (By similarity).
-!- INTERACTION:
Q9H1J2:-; NbExp=1; IntAct=EBI-372110, EBI-372073;
P21964:COMT; NbExp=1; IntAct=EBI-372110, EBI-372265;
Q9NPK4:DOM3Z; NbExp=1; IntAct=EBI-372110, EBI-372173;
Q9Y262:EIF3S6IP; NbExp=1; IntAct=EBI-372110, EBI-373519;
Q7Z4L1:EIF5A; NbExp=1; IntAct=EBI-372110, EBI-373150;
Q01780:EXOSC10; NbExp=1; IntAct=EBI-372110, EBI-358236;
Q96B26:EXOSC8; NbExp=1; IntAct=EBI-372110, EBI-371922;
P56537:ITGB4BP; NbExp=1; IntAct=EBI-372110, EBI-372243;
P62310:LSM3; NbExp=1; IntAct=EBI-372110, EBI-348239;
O95396:MOCS3; NbExp=1; IntAct=EBI-372110, EBI-373206;
P25788:PSMA3; NbExp=1; IntAct=EBI-372110, EBI-348380;
Q13148:TARDBP; NbExp=1; IntAct=EBI-372110, EBI-372899;
Q7Z3E1:TIPARP; NbExp=1; IntAct=EBI-372110, EBI-373532;
Q9H0E2:TOLLIP; NbExp=1; IntAct=EBI-372110, EBI-74615;
-!- SUBCELLULAR LOCATION: Nuclear; nucleolar.
-!- TISSUE SPECIFICITY: Expressed in the spleen, thymus, prostate,
testis, ovary, small intestine, colon, peripheral blood leukocyte,
heart, brain, placenta, lung, liver, skeletal muscle, kidney, and
pancreas.
-!- SIMILARITY: Belongs to the 5'-3' exonuclease family.
-!- SIMILARITY: Contains 1 CCHC-type zinc finger.
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Sequence length: 950
MGVPAFFRWL SRKYPSIIVN CVEEKPKECN GVKIPVDASK PNPNDVEFDN LYLDMNGIIH
PCTHPEDKPA PKNEDEMMVA IFEYIDRLFS IVRPRRLLYM AIDGVAPRAK MNQQRSRRFR
ASKEGMEAAV EKQRVREEIL AKGGFLPPEE IKERFDSNCI TPGTEFMDNL AKCLRYYIAD
RLNNDPGWKN LTVILSDASA PGEGEHKIMD YIRRQRAQPN HDPNTHHCLC GADADLIMLG
LATHEPNFTI IREEFKPNKP KPCGLCNQFG HEVKDCEGLP REKKGKHDEL ADSLPCAEGE
FIFLRLNVLR EYLERELTMA SLPFTFDVER SIDDWVFMCF FVGNDFLPHL PSLEIRENAI
DRLVNIYKNV VHKTGGYLTE SGYVNLQRVQ MIMLAVGEVE DSIFKKRKDD EDSFRRRQKE
KRKRMKRDQP AFTPSGILTP HALGSRNSPG SQVASNPRQA AYEMRMQNNS SPSISPNTSF
TSDGSPSPLG GIKRKAEDSD SEPEPEDNVR LWEAGWKQRY YKNKFDVDAA DEKFRRKVVQ
SYVEGLCWVL RYYYQGCASW KWYYPFHYAP FASDFEGIAD MPSDFEKGTK PFKPLEQLMG
VFPAASGNFL PPSWRKLMSD PDSSIIDFYP EDFAIDLNGK KYAWQGVALL PFVDERRLRA
ALEEVYPDLT PEETRRNSLG GDVLFVGKHH PLHDFILELY QTGSTEPVEV PPELCHGIQG
KFSLDEEAIL PDQIVCSPVP MLRDLTQNTV VSINFKDPQF AEDYIFKAVM LPGARKPAAV
LKPSDWEKSS NGRQWKPQLG FNRDRRPVHL DQAAFRTLGH VMPRGSGTGI YSNAAPPPVT
YQGNLYRPLL RGQAQIPKLM SNMRPQDSWR GPPPLFQQQR FDRGVGAEPL LPWNRMLQTQ
NAAFQPNQYQ MLAGPGGYPP RRDDRGGRQG YPREGRKYPL PPPSGRYNWN