|
|
|
|
|
|
Description:
Exodeoxyribonuclease I (EC 3.1.11.1) (Exonuclease I) (DNAdeoxyribophosphodiesterase) (dRPase).
Molecular weight: 57565
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
07-MAR-2006, entry version 19.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Buchnera.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein EX1_BUCAP:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE014127 | AAM68078.1 | - |
| HSSP | P04995 | 1FXX | |
| GenomeReviews | AE013218_GR | BUsg537.1 | |
| InterPro | IPR006055 | Exonuclease. | |
| InterPro | IPR012337 | RNaseH_fold. | |
| Pfam | PF00929 | Exonuc_X-T | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Exonuclease; Hydrolase; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT "50 million years of genomic stasis in endosymbiotic bacteria.";
RL Science 296:2376-2379(2002).
Feature:
CHAIN 1 482 Exodeoxyribonuclease I.
/FTId=PRO_0000087108.
Comments:
-!- FUNCTION: Also functions as a DNA deoxyribophosphodiesterase that
release deoxyribose-phosphate moieties following the cleavage DNA
at an apurinic/apyrimidinic (AP) site by either an AP endonuclease
AP lyase (By similarity).
-!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in the 3'- to 5'-
direction to yield nucleoside 5'-phosphates.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 482
MKNILKKNEV NFLFYDYETF GIHTSLDKPA QFSSIRTDKN FNIMEEPKCF YCFPSDDYLP
DPSSILITGI TPEYTEKHGF NEYKFSKKIH DVLLKPNTCI IGYNNINFDD EITRNIFYRN
FLDPYEWSWK NNNSRWDLLN VVRACYALRP SGIQWPKNEF GLPVFKLSDL TQKNNISHYN
AHDATSDVYA TIELAKLIKR KQPKLFDFFF KYRKKNELCR LIDIEKFTPI IYVSSYFGAL
RQNMSCILPL SWDLHNKNIL ISIDLFKDID KLIVFCKTVS ISNISIKDLF DLGIVLVYLN
RCPILAPIKV IRKEDTNRLN FKKYFYYKKI NLVKKNYFLI DLVKNVLLKK NENKNSLNVD
LQIYDSFFNF HDKNLIKKIS LTKSSDLKKM KLDFKDPRLK ELFFRYKARN FFNILKNDEK
KEWINYCLKT LNSFFLTGYI DKIESLLKIY SYDVKKNNLL SDLLKYVFKK YKKVFYKNIN
LS