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Description:
Exodeoxyribonuclease V alpha chain (EC 3.1.11.5).
Molecular weight: 70408
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Buchnera.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein EX5A_BUCAP:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE014120 | AAM67983.1 | - |
| GenomeReviews | AE013218_GR | BUsg440.1 | |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR006344 | RecD. | |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR01447 | recD | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; Endonuclease; Exonuclease; Helicase; Hydrolase; Nuclease; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT "50 million years of genomic stasis in endosymbiotic bacteria.";
RL Science 296:2376-2379(2002).
Feature:
CHAIN 1 602 Exodeoxyribonuclease V alpha chain.
/FTId=PRO_0000087113.
NP_BIND 174 181 ATP (Potential).
Comments:
-!- FUNCTION: Exhibits several catalytic activities, including ATP-
dependent exonuclease, ATP-stimulated endonuclease, ATP-dependent
unwinding and DNA-dependent ATPase activities. Strand cleavage
occurs 5' to 3' during the unwinding of duplex DNA at CHI
sequences, which locally stimulate recombination (By similarity).
-!- CATALYTIC ACTIVITY: Exonucleolytic cleavage (in the presence of
ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-
phosphooligonucleotides.
-!- SUBUNIT: Consist of three subunits; recB, recC and recD (By
similarity).
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Sequence length: 602
MNMSHLLQNF ANKKIITLVD FYFSQFISKK NSIIMLISAC VSFESKNGHI FLPIEYFEKN
CFFSISNKQF INKILKCLNK KKINWSLELS EHISCGDGSI ITPLVFYKDK IYLYKIWKAE
KKILERLYEK NQFDTIDTQQ CLNILNNLFS KKKHDLQKIA VILTLINNII FITGGPGTGK
TTIILKIIIA LIKNAKKKIK IQLSAPTGKA TENLIEILND KWLNRYLLKE EKKQFSFNPI
MTIHQLLGIS KKSEKIFFNK NNLLMIDILI IDEASMIDIL MMSNILSALS KKTKIIFIGD
HNQLKPVKSS SILKYICSYA EDGYSLKTQS ILQEITQNSI INYKINKKNT SYISDKICVL
KKSYRFEKKT GIYILSNAVY NKETKIFEKL FKNSIENVFF YEINSEIEYK KMINIIINNN
KIFWRKIYEK KNIKEIIKTF KNHQILCIVK NGFFGVNFIN KILEEEMYKR NIFNKRFYIN
NKLWYIGKPI IITENNQCLG IFNGEIGITN LSQKNTLQVS FLKKDNFIEN IPIEILKNYK
TSWSITVHKA QGSEFNNISL ILPNKNLKIL KKDILYTGIT RTRKQLNIFS TKEIFIKTVL
KN