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Description:
DNA mismatch repair protein mutL.
Molecular weight: 67945
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Buchnera.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_BUCAP:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE014129 | AAM68088.1 | - |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE013218_GR | BUsg550.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT "50 million years of genomic stasis in endosymbiotic bacteria.";
RL Science 296:2376-2379(2002).
Feature:
CHAIN 1 582 DNA mismatch repair protein mutL.
/FTId=PRO_0000177932.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 582
MQPIRMLSSS LSSQISAGEV IERPSSVIKE LLENSIDAQA KNIDISVERS GLNSITVKDD
GFGIEKDQLL LAISRHATSK INRLSDLDNI NTFGFRGEAL ASIRAVSRMK LISCSQNSNI
AWSIYSEGFS NHTLLQPIAH PIGTSIIVDN LFYNIPVRLK FIKNERSEFL KIDETIKKIA
LSNFGINIFF KKDKKLFVSY KAITKNNNKI HRLKTVFNQI DLNYVLEIKE KMHNITLFGW
LIFPSSLSST FKKIQYCYVN NRFVYNNLIK SAVFNSFYEI IGNKRSTSFI LYLTLPSNEI
DINIHPTKNE IKFHKSNIIY FFVYQSILSS LKKCKIKYIS NNFFLKTHSN KCKNNNSDSL
NTKLVSQIHS KYEKKDLYKD VISTDLFKIN SQRFLKEYFF SFGKLLIVFQ KYYGLMYYSN
TFSLISFPLA KKIVEQYKLR SAIKNNMIPE IFSYNFLYFI TFKQNKILSN NLKLLLKFGF
NLILKEKYFF LKTIPIFLKN QNLDVLLSSF FSFIFFKKKI YIKDIIKWFD TTILIEKNSW
NYEDGISILL EIEYFCPSIF KKPPLKLLQK INVDEVLCIL KV