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Description:
DNA mismatch repair protein mutS.
Molecular weight: 92255
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Buchnera.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_BUCAP:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE014117 | AAM67959.1 | - |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AE013218_GR | BUsg414.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT "50 million years of genomic stasis in endosymbiotic bacteria.";
RL Science 296:2376-2379(2002).
Feature:
CHAIN 1 805 DNA mismatch repair protein mutS.
/FTId=PRO_0000115080.
NP_BIND 617 624 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 805
MTETNFSTKN SNHTPMIKQY LSLKSQYPNM LLFYQMGDFY ELFYEDAKRV SRLLKITLTK
KGNSNNNIIP MAGVPCHTAE YYLSKLVKMG ESIAVCDQIK DVYSEKKLLT RQVVRVITPG
TITDEAFLEE NKDNFIAAVW KENNKFAYAI LDISLGFFGV SEHFDRNSLL SEIERTNPTE
LLYPENFEDM LLISHKKCIQ KRPLLDFDIK ISYKLLTLQF KTSNLNGFGI KKNHFVIRPA
GCLINYIKLM HISFLPHIRK IQFNYIENNI FMNSSTRKSL EIIESISGES KNTLSSVLNK
TVTSMGGRLL NRWLNTPSKD LSLIKNRHGM VKLLRPFYKE IQCILRQVSD LERICSRLAL
RTALPRDFVR MRSTLNILPD LCLILKKIKS TSINNVLMSI GKFEKILFLL KKSINLTVPS
SIRDGGVIAC NYNKKLDELR SLKKNSQKYL QDFEVKEKSR LNIDSFKIGY NNIVGYYIQV
NKRHSHLIPH SYLKIQTLKN VERYSVPLLK NYEKQVISAK FQAIFLEKTL YMELFDIIEP
FLEDLKNSAF ALSELDVLVN LSERSISLNY VCPKMTKKYG ITLVESRHPV VECFLENPFI
SNSVDLSKKN RMLIITGPNM GGKSTYMRQV ALIIIMACIG SFVPAKYASI GLIDKIFTRI
GSADDVSNGY STFMMEMTEI SNILHNATCN SLILIDELGR GTSNKDGLAL AWSCSKYLMT
KNKSMILLST HFIELTKLEN FFKNIKNFYF SAFEHDSNIA FLYKIKKGIS KKSYGIAVAS
LSGIPDIVIQ DAKKKLIELE SDNVF