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Description:
Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (EC 3.6.1.-) (dGTP pyrophosphohydrolase).
Molecular weight: 16090
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Buchnera.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTT_BUCAP:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE014095 | AAM67760.1 | - |
| HSSP | P08337 | 1TUM | |
| GenomeReviews | AE013218_GR | BUsg196.1 | |
| InterPro | IPR000086 | NUDIX_hydrolase. | |
| Pfam | PF00293 | NUDIX | 1. |
| PRINTS | PR00502 | NUDIXFAMILY. | |
| PROSITE | PS00893 | NUDIX | FALSE_NEG. |
Keywords:
Complete proteome; DNA damage; DNA repair; DNA replication; Hydrolase; Magnesium; Mutator protein.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT "50 million years of genomic stasis in endosymbiotic bacteria.";
RL Science 296:2376-2379(2002).
Feature:
CHAIN 1 130 Mutator mutT protein.
/FTId=PRO_0000056945.
MOTIF 37 58 Nudix box.
Comments:
-!- FUNCTION: Involved in the GO system responsible for removing an
oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine)
from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite
dA and dC residues of template DNA with almost equal efficiency
thus leading to A.T to G.C transversions. MutT specifically
degrades 8-oxo-dGTP to the monophosphate (By similarity).
-!- CATALYTIC ACTIVITY: 8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.
-!- COFACTOR: Magnesium (By similarity).
-!- SUBUNIT: Monomer (By similarity).
-!- SIMILARITY: Belongs to the Nudix hydrolase family.
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Sequence length: 130
MKYTNIVIGI IIKKNKIYIT KARKKKYVLD LWEFPGGKVK ENENLTYSLK RELSEEVGLK
ILRFRFFRCI KYFYKKIKLY FFLITRWKGR IYSKEGYLYK WIFLDDLKYF NFPSPNSHII
HDLQKMIFFK