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Description:
A/G-specific adenine glycosylase (EC 3.2.2.-).
Molecular weight: 41301
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
07-MAR-2006, entry version 27.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Buchnera.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTY_BUCAP:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE014127 | AAM68075.1 | - |
| HSSP | P17802 | 1KG2 | |
| GenomeReviews | AE013218_GR | BUsg534.1 | |
| InterPro | IPR003265 | Endo_3c. | |
| InterPro | IPR004035 | EndoIII_FCL. | |
| InterPro | IPR004036 | EndoIII_HhH. | |
| InterPro | IPR003651 | FeS_bind. | |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR013003 | MutY. | |
| InterPro | IPR005760 | MutY_bac. | |
| PANTHER | PTHR10359:SF3 | MutY.1 | 1. |
| Pfam | PF00633 | HHH | 1. |
| Pfam | PF00730 | HhH-GPD | 1. |
| SMART | SM00478 | ENDO3c | 1. |
| SMART | SM00525 | FES | 1. |
| TIGRFAMs | TIGR01084 | mutY | 1. |
| PROSITE | PS00764 | ENDONUCLEASE_III_1 | 1. |
| PROSITE | PS01155 | ENDONUCLEASE_III_2 | 1. |
Keywords:
4Fe-4S; Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase; Iron; Iron-sulfur; Metal-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT "50 million years of genomic stasis in endosymbiotic bacteria.";
RL Science 296:2376-2379(2002).
Feature:
CHAIN 1 347 A/G-specific adenine glycosylase.
/FTId=PRO_0000102232.
METAL 192 192 Iron-sulfur (4Fe-4S) (By similarity).
METAL 199 199 Iron-sulfur (4Fe-4S) (By similarity).
METAL 202 202 Iron-sulfur (4Fe-4S) (By similarity).
METAL 208 208 Iron-sulfur (4Fe-4S) (By similarity).
Comments:
-!- FUNCTION: Adenine glycosylase active on G-A and C-A mispairs (By
similarity).
-!- COFACTOR: Binds 1 4Fe-4S cluster which is not important for the
catalytic activity, but which is probably involved in the proper
positioning of the enzyme along the DNA strand (By similarity).
-!- SIMILARITY: Belongs to the nth/mutY family.
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Sequence length: 347
MTIYVFSQLI LNWYHINGRK NLPWKKDKTL YKVWISEIML QQTTVKTAIP YFKNFISRFP
NIQSLNQSKL DDILCLWSGL GYYKRAENIY KTVKIIKEEF QEKFPTGFSD LIKLPGIGRS
TAGAILSLSL DYFFPILEGN VKRILMRYYG IIGYVTEKKI EQKLWYLIEL ITPIHNTGSF
NQGIMDIGAL ICTPKNPKCN LCPLIQKCIA YKEKNWIKYP LKKKKKIILE KKSWFVVIKY
QNQFWIEKNT EKKIWKNLFC FPNFDTKIKT IEWLKKNKIN IDKKHKKIQS FYHKFSHFTL
HIIPILVNLS FFKNFQNSKK TGIWYDLKNT HDIGLPKPVQ KILEIFK