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Description:
ATP-dependent DNA helicase rep (EC 3.6.1.-).
Molecular weight: 77509
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
07-MAR-2006, entry version 33.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Buchnera.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein REP_BUCAP:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF008210 | AAC38127.1 | - |
| EMBL | AE014131 | AAM68108.1 | - |
| HSSP | P09980 | 1UAA | |
| GenomeReviews | AE013218_GR | BUsg574.1 | |
| InterPro | IPR005752 | DNA_hel_RepA. | |
| InterPro | IPR000212 | UvrD-helicase. | |
| PANTHER | PTHR11070 | UvrD-helicase.1 | 1. |
| Pfam | PF00580 | UvrD-helicase | 1. |
| TIGRFAMs | TIGR01074 | rep | 1. |
Keywords:
ATP-binding; Complete proteome; DNA replication; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=98184963; PubMed=9516544;
RA Clark M.A., Baumann L., Baumann P.;
RT "Sequence analysis of a 34.7-kb DNA segment from the genome of
RT Buchnera aphidicola (endosymbiont of aphids) containing groEL, dnaA,
RT the atp operon, gidA, and rho.";
RL Curr. Microbiol. 36:158-163(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT "50 million years of genomic stasis in endosymbiotic bacteria.";
RL Science 296:2376-2379(2002).
Feature:
CHAIN 1 658 ATP-dependent DNA helicase rep.
/FTId=PRO_0000102066.
NP_BIND 22 29 ATP (Potential).
Comments:
-!- FUNCTION: Rep helicase is a single-stranded DNA-dependent ATPase
involved in DNA replication; it can initiate unwinding at a nick
in the DNA. It binds to the single-stranded DNA and acts in a
progressive fashion along the DNA in the 3' to 5' direction (By
similarity).
-!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
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Sequence length: 658
MSLNFNQKNA IELINGPCLI LAGAGSGKTK VIINKIIYLI NNCQYKPGNI IAVTFTNKAA
HEIKVRLAKH LNLLQIKKMI ISTFHSLGLE IIKKEINTLK FNSNFSLFDE RDQMMLLKKI
CSKSIKNDTK LLKKLVFMIS FWKNKFLTPL QVQLSAQSNL EKDFAFFYKQ YTFHLRKSNI
LDFDDLICIP TSLLKNNQII QNRWQKKISY LLVDEYQDTN NSQYELIKML TNVNSNFTLV
GDDDQSIYSW RGAKPQNLFL IKKDFPNLKI IKMEQNYRSY GRILKAANKL ISNNLHYFKK
KLFSNLEYGN KIKVIIGKNE KNEAEKIADK IIHECSNDIM QYKDYAILYR GNYQSQILEK
TFLKKNIPYD ISTNSSFFSR PEIKDLLSYL RLIVNPDDNH AFIRILNIPH RQIGLTTLNK
LEELASKKNK SLFQISNDIE IKKILRERTV KKIKDFIYWI KKIIKLSLLK EDIILDKIIN
DIKYELWLTK ILKEPKKIKT SINNIYTLSN WLKEMLRGNE FEKPMNLLQI VKKMTLRDIL
EKKIQINEIP KNRVQLMTLH SSKGLEFSSV FIIGMNEGIL PNIKSINNDN IEEERRLTYV
GMTRARKELF FTYCQTRIQY GQKLYTAPSR FLFELPQEDL QWEKDDYLDA FHTKEKKI